2010 Fiscal Year Final Research Report
Antitumor effect of bone marrow mesenchymal stem cell to Ewing sarcoma
| Project/Area Number |
20790729
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Okayama University |
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Principal Investigator |
MIYAMURA Takako Okayama University, 岡山大学病院, 助教 (20379796)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 移植・再生医療 / 間葉系幹細胞 / 細胞・組織 / 癌 |
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| Research Abstract |
It has been reported that mesenchymal stem cell(MSC) could induce apoptosis in various cancer cells. Moreover, MSC can target injured part. We planned to investigate about the following ; (1) Antitumor effect to Ewing sarcoma of normal MSC (2) Amplification of antitumor effect of anti-cancer drugs (including bisphosphonate) by coculture with MSC. It tended to obtain the higher anti-tumor effects to the Ewing sarcoma cell line by coculuture of MSC and anti-tumor agents. We evaluated the ability of MSC as the delivery vehicles of the anti-cancer drugs to achieve the higher antitumor effects, and it is necessary to continue a further research.
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