• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

Antitumor effect of bone marrow mesenchymal stem cell to Ewing sarcoma

Research Project

  • PDF
Project/Area Number 20790729
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionOkayama University

Principal Investigator

MIYAMURA Takako  Okayama University, 岡山大学病院, 助教 (20379796)

Project Period (FY) 2008 – 2010
Keywords移植・再生医療 / 間葉系幹細胞 / 細胞・組織 / 癌
Research Abstract

It has been reported that mesenchymal stem cell(MSC) could induce apoptosis in various cancer cells. Moreover, MSC can target injured part. We planned to investigate about the following ; (1) Antitumor effect to Ewing sarcoma of normal MSC (2) Amplification of antitumor effect of anti-cancer drugs (including bisphosphonate) by coculture with MSC. It tended to obtain the higher anti-tumor effects to the Ewing sarcoma cell line by coculuture of MSC and anti-tumor agents. We evaluated the ability of MSC as the delivery vehicles of the anti-cancer drugs to achieve the higher antitumor effects, and it is necessary to continue a further research.

  • Research Products

    (14 results)

All 2010 2009 2008

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (7 results)

  • [Journal Article] Successful treatment of unresectable advanced hepatoblastoma : Living liver transplantation after surgical removal of lung metastasis.2010

    • Author(s)
      Miyamura T, Chayama K, Morishima T., et al.
    • Journal Title

      Pediatr.Transplant. Epub

    • Peer Reviewed
  • [Journal Article] Outcome of recurrent or refractory acute lymphoblastic leukemia in infants with MLL gene rearrangements : A report from the Japan Infant Leukemia Study Group2009

    • Author(s)
      Tomizawa D, Koh K, Miyamura T, Ishii E, et al.
    • Journal Title

      Pediatr Blood Cancer. 52(7)

      Pages: 808-13

    • Peer Reviewed
  • [Journal Article] 悪性骨軟部腫瘍に対する治療の工夫小児(15歳以下)Ewing肉腫/PNETの治療成績2009

    • Author(s)
      国定俊之, 宮村能子, 尾崎敏文, ほか
    • Journal Title

      中部日本整形外科災害外科学会雑誌 52巻4号

      Pages: 839-840

  • [Journal Article] リツキシマブ併用化学療法を行った再発急性リンパ性白血病の2例2009

    • Author(s)
      鷲尾佳奈、宮村能子, 小田慈, 森島恒雄, ほか
    • Journal Title

      日本小児血液学会雑誌 23巻1号

      Pages: 37-42

    • Peer Reviewed
  • [Journal Article] Two cases of chronic active Epstein-Barr virus infection in which EBV-specific cytotoxic Tlymphocyte was induced after allogeneic bone marrow transplantation.2008

    • Author(s)
      Miyamura T, Chayama K, Morishima T, et al.
    • Journal Title

      Pediatr Transplant. 12(5)

      Pages: 588-92

    • Peer Reviewed
  • [Journal Article] Identification of the HERV-Kgag antigen in prostate cancer by SEREX using autologous patient serum and its immunogenicity.2008

    • Author(s)
      Ishida T, Miyamura T, Nakayama E, et al.
    • Journal Title

      Cancer Immun. 13;8

      Pages: 15

    • Peer Reviewed
  • [Journal Article] 胃原発バーキソトリンパ腫の1例2008

    • Author(s)
      宮村能子, 茶山公祐, 森島恒雄, ほか
    • Journal Title

      日本小児科学会雑誌 112巻8号

      Pages: 1271-1274

    • Peer Reviewed
  • [Presentation] 乳児急性リンパ性白血病再発症例の後方視敵検討-JPSLG MLL03臨床試験より-2010

    • Author(s)
      宮村能子, ほか
    • Organizer
      第52回日本小児血液学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-19
  • [Presentation] 自家移植併用大量化学療法を施行し放射線治療を行わず寛解を維持している乳児脈絡叢癌の2例2010

    • Author(s)
      宮村能子, ほか
    • Organizer
      第26回日本小児がん学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-17
  • [Presentation] Nation-Wide Survey of Relapsed Infantile Acute Lymphoblastic Leukemia in Japan : Treatment and Outcome From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) MLL03 Study.2010

    • Author(s)
      Takako Miyamura, et al.
    • Organizer
      52nd American Society of Hematology(ASH)
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2010-12-04
  • [Presentation] 発症時よりRSV感染をみとめ致死的経過をたどった乳児急性骨髄性白血病の1例2009

    • Author(s)
      宮村能子, ほか
    • Organizer
      第51回日本小児血液学会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-29
  • [Presentation] Nation wide survey of infant leukemia in Japan. a report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG).2008

    • Author(s)
      Takako Miyamura, et al
    • Organizer
      50th American Society of Hematology(ASH)
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-12-06
  • [Presentation] 乳児期発症の白血病について後方視的全国調査2008

    • Author(s)
      宮村能子, ほか
    • Organizer
      第50回日本小児血液学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2008-11-16
  • [Presentation] 肺転移巣切除後生体肝移植を施行した進行肝芽腫の1例2008

    • Author(s)
      宮村能子, ほか
    • Organizer
      第24回日本小児がん学会
    • Place of Presentation
      千葉
    • Year and Date
      2008-11-15

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi