2010 Fiscal Year Final Research Report
Analysis of heme oxygenase-1 in secondary hemophagocytic syndrome
| Project/Area Number |
20790741
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
YOSHIYAMA Megumi Wakayama Medical University, 医学部, 助教 (00433368)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 小児血液学 |
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| Research Abstract |
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening conditions characterized by uncontrolled activation of T-cells and macrophages. The precise mechanism leading to the development of immune response dysregulation resulting in hypercytokinemia has not been well evaluated. We speculated that heme oxygenase-1 might be involved in the abnormal immune reactions in acquired HLH. Serum levels of heme oxygenase-1 were elevated in HLH patients and our results suggest that heme oxygenase-1 might be a useful bio-marker of HLH.
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