2010 Fiscal Year Final Research Report
Role of Angiotensin II in coronary artery lesion of Kawasaki disease
| Project/Area Number |
20790750
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Tokai University |
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Principal Investigator |
SUGANUMA Eisuke Tokai University, 医学部, 助教 (60408010)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 小児循環器 |
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| Research Abstract |
Extracellular matrix(ECD) such as INF-γ,TNF-α,IL-6,MMPs are thought to be involved in coronary artery lesions (CAL) in patients with Kawasaki disease (KD). The mechanisms underlying effects of ARB in CAL are not known. We discussed whether ARB could prevent Lactobacillus casei cell wall extract (LCWE)-induced coronary arteritis in murine model of KD. Inflammations in response to LCWE, are suppressed by ARB treatment. More interestingly, MMP-2, MMP-9, IL-6 mRNA expression at local coronary artery significantly decreased in mice treated with ARB compared with mice post-LCWE injection. Thus, this result suggests that ARB is expected to be a new therapeutic agent for preventing CAL in patient with Kawasaki disease.
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