2009 Fiscal Year Final Research Report
Establishment of treatment strategy for rodents with afterloaded right ventricle dysfunction by using physilogic analysis.
| Project/Area Number |
20790751
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
URASHIMA Takashi Jikei University School of Medicine, 医学部, 助教 (20338875)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 右心不全 / ラット / 小児 |
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| Research Abstract |
To evaluate progression of afterloaded right ventricle (RV) remodeling, molecular and physiologic examination were performed in a murine model of pulmonary artery stenosis. Afterloaded RV was showing a dilatation of camber and fibrosis compared with afterloaded left ventricle (LV). Pro-collagen was elevated in afterloaded RV not LV by using RT-PCR. These results suggested that treatment fibrosis in RV is useful to prevent decompensated RV heart failure.
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[Journal Article] Yang Multimodality Evaluation of the Viability of Stem Cells Delivered Into Different Zones of Myocardial Infarction2008
Author(s)
Ta-Chuan Hung, Yoriyasu Suzuki, Takashi Urashima, Anthony Caffarelli, Grant Hoyt, Ahmad Y. Sheikh, Alan C. Yeung, Irving Weissman, Robert C. Robbins, Jeff M. Bulte, Phillip C
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Journal Title
Circ Cardiovasc Imaging 1(1)
Pages: 6-13
Peer Reviewed
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