2010 Fiscal Year Final Research Report
Analysis of Toll-like receptor signal transduction in acute Kawasaki disease.
| Project/Area Number |
20790757
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Gunma University |
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Principal Investigator |
KOBAYASHI Tohru Gunma University, 大学院・医学系研究科, 助教 (50431713)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 川崎病 / Toll-like receptor / 遺伝子 |
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| Research Abstract |
We examined gene expressions of Toll-like receptor signal transduction in acute phase of Kawasaki disease. In Kawasaki disease, gene expression of CD14, IRF7, CREB3, and IL1RL1 was stimulated. On the other hands, gene expression of TLR6, TICAM2, UBE2N, TLR9, LBP was repressed.
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[Journal Article] External Validation of a Risk Score to Predict Intravenous Immunoglobulin Resistance in Patients With Kawasaki Disease.2011
Author(s)
Seki M, Kobayashi T, Kobayashi T, Morikawa A, Otani T, Takeuchi K, Ayusawa M, Tsuchiya K, Yasuda K, Suzuki T, Shimoyama S, Ikeda K, Ishii Y, Arakawa H.
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Journal Title
Pediatr Infect Dis J. 30
Pages: 145-147
Peer Reviewed
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[Journal Article] Risk stratification in the decision to include prednisolone with intravenous immunoglobulin in primary therapy for Kawasaki disease.2009
Author(s)
Kobayashi T, Inoue Y, Otani T, Morikawa A, Kobayashi T, Takeuchi K, Saji T, Sonobe T, Ogawa S, Miura M, Arakawa H.
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Journal Title
Pediatr Infect Dis J. 28
Pages: 498-502
Peer Reviewed
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[Presentation] A new scoring system to predict intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease.2008
Author(s)
Shinya Shimoyama, Tohru Kobayashi, Yoshinari Inoue, Kazuo Takeuchi, Tomio Kobayashi, Yasunori Okada, Kazushi Tamura, Takeshi Tomomasa, Tetuya Otani, Hirokazu Arakawa, Akihiro Morikawa.
Organizer
14^<th> World Congress on Heart Disease, The International Academy of Cardiology Annual Scientific Sessions 2008
Place of Presentation
Toronto, Canada
Year and Date
2008-07-28
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[Presentation] Risk stratification in the decision to include prednisolone with intravenous immunoglobulin in primary therapy of Kawasaki disease.2008
Author(s)
Tohru Kobayashi, Yoshinari Inoue, Tetsuya Otani, Tomio Kobayashi, Kazuo Takeuchi, Tsutomu Saji, Tomoyoshi Sonobe, Shunichi Ogawa, Masaru Miura, Mitsuru Seki, Kentaro Ikeda, Yoichiro Ishii, Takahiro Suzuki, Shinya Shimoyama, Akihiro Morikawa.
Organizer
Pediatric Academic Society 2008
Place of Presentation
Honolulu, Hawaii, USA
Year and Date
2008-05-04
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[Presentation] External Validation Of A Risk Score To Predict Intravenous Immunoglobulin Unresponsiveness In Patients With Kawasaki Disease2008
Author(s)
Mitsuru Seki, Tohru Kobayashi, Yoshinari Inoue, Mamoru Ayusawa, Takahiro Nakamura, Tomio Kobayashi, Kentaro Ikeda, Yoichiro Ishii, Takahiro Suzuki, Shinya Shimoyama, Akihiro Morikawa.
Organizer
Pediatric Academic Society 2008
Place of Presentation
Honolulu, Hawaii, USA
Year and Date
2008-05-04
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[Presentation] Risk stratification in the decision to include prednisolone with intravenous immunoglobulin in primary therapy of Kawasaki disease.2008
Author(s)
Takahiro Suzuki, Tohru Kobayashi, Yoshinari Inoue, Tetsuya Otani, Tomio Kobayashi, Kazuo Takeuchi, Mitsuru Seki, Kentaro Ikeda, Yoichiro Ishii, Shinya Shimoyama, Morikawa Akihiro.
Organizer
9^<th> International Kawasaki Disease Symposium.
Place of Presentation
Taipei, Taiwan
Year and Date
2008-04-12
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