2009 Fiscal Year Final Research Report
Investigation of roles of DSCAM in mental retardation of Down syndrome
| Project/Area Number |
20790758
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
AMANO Kenji The Institute of Physical and Chemical Research, 神経遺伝研究チーム, リサーチアソシエイト (60333340)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ダウン症候群 / 精神遅滞 / Ts1Cje / DSCAM |
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| Research Abstract |
Ts1Cje, a mouse model of Down syndrome, shows several abnormal phenotypes including decreased body weight, deficient spatial memory in Y-maze task, and enlarged brain ventricles that might relate to the mental retardation of Down syndrome. I compared these phenotypes between Ts1Cje and Ts1Cje-Dscam(+/+/-) mice to investigate the roles of DSCAM, but the phenotypes were not improved in Ts1Cje-Dscam(+/+/-) mice. These results suggest that the overexpression of DSCAM does not lead to these phenotypes in Ts1Cje mice.
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