2009 Fiscal Year Final Research Report
Role of cholesterol in development of serotonergic and dopaminergic systems.
| Project/Area Number |
20790767
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAKATA Hiromi The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 講師 (50294666)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 脳発達障害 / コレステロール / セロトニン / ドーパミン / 不安様行動 |
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| Research Abstract |
We examined the role of cholesterol and serotonin in prenatal brain development. A moderate level of cholesterol deficiency during the prenatal period did not affect development of the serotonergic and dopaminergic systems in rat fetuses. However, rats exposed to a inhibitor of an enzyme for serotonin synthesis showed a increased reactivity to conditioned fear during an elevated T-maze behavioral test. Prenatal brain serotonin might affect the sensitivities to adverse stimuli after birth.
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