2009 Fiscal Year Final Research Report
Analysis of the mechanism for dendritic cell maturation by haptens
| Project/Area Number |
20790785
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Tohoku University |
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Principal Investigator |
MIZUASHI Masato Tohoku University, 病院, 助教 (20400369)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 樹状細胞 / ハプテン / チオール基 / ER stress / 血小板 / CD40 ligand |
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| Research Abstract |
In this study, we examined whether sensitizers oxidize cell surface thiols of monocyte-derived dendritic cells (MoDCs). All the sensitizers that we examined decreased cell surface thiols on MoDCs. Our data suggest that the oxidation of cell surface thiols have some role in triggering DC maturation by sensitizers. In addition, we also suggest that both ER stress and CD40 ligand derived from platelets are related to DC maturation by sensitizers.
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