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2009 Fiscal Year Final Research Report

analysis of function about keratinocyte differentiation of p51/p63, homologue of tumor suppressor gene p53

Research Project

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Project/Area Number 20790786
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionTohoku University

Principal Investigator

OKAWA Eisaku  Tohoku University, 大学院・医学系研究科, 助教 (20451586)

Project Period (FY) 2008 – 2009
Keywords発生・分化 / 表皮細胞分化 / p51 / p63 / p53
Research Abstract

I found that p63 was related to the mechanism of keratin 1 expression in keratinocyte differentiation. p63 induces keratin 1 via JNK/AP-1 activation. I explained keratinocyte growth factor, from dermal fibroblast, suppressed keratin 1 expression via ERK signaling.I examined the relationship between p63 and sonic hedgehog. I overexpressed p63 in keratinocyte and showed the promoter activity of sonic hedgehog increased. In vivo, I showed that p63 expressed strongly in basal cell carcinoma by immunostaining method.

  • Research Products

    (4 results)

All 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Ectopic expression of the p53 homologue p63 is linked to squamous metaplasia in extramammary Paget's disease with invasive adenocarcinoma.2009

    • Author(s)
      E Ogawa, R Okuyama, T Egawa, H Nagoshi, H Tagami, S Ikawa, S Aiba
    • Journal Title

      Histopathology 54

      Pages: 374-393

    • Peer Reviewed
  • [Journal Article] p63/p51-induced Onset of Keratinocyte Differentiation via the c-Jun N-terminal Kinase Pathway Is Counteracted by Keratinocyte Growth Factor.2008

    • Author(s)
      E Ogawa, R Okuyama, T Egawa, H Nagoshi, M Obinata, H Tagami, S Ikawa, S Aiba
    • Journal Title

      THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 283,NO.49

      Pages: 34241-34249

    • Peer Reviewed
  • [Presentation] p63 prevents growth arrest via Sonic hedgehog induction2009

    • Author(s)
      小川英作、奥山隆平、岡田修子、井川俊太郎、相場節也
    • Organizer
      日本研究皮膚科学会第34回年次学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2009-12-04
  • [Presentation] Notch2 down-regulation in wound healing is contributed to acceleration of cell motility2009

    • Author(s)
      奥山隆平、斉藤るみ子、小川英作、井川俊太郎、相場節也
    • Organizer
      日本研究皮膚科学会第34回年次学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2009-12-04

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Published: 2011-06-18   Modified: 2016-04-21  

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