2009 Fiscal Year Final Research Report
analysis of function about keratinocyte differentiation of p51/p63, homologue of tumor suppressor gene p53
| Project/Area Number |
20790786
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Tohoku University |
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Principal Investigator |
OKAWA Eisaku Tohoku University, 大学院・医学系研究科, 助教 (20451586)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 発生・分化 / 表皮細胞分化 / p51 / p63 / p53 |
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| Research Abstract |
I found that p63 was related to the mechanism of keratin 1 expression in keratinocyte differentiation. p63 induces keratin 1 via JNK/AP-1 activation. I explained keratinocyte growth factor, from dermal fibroblast, suppressed keratin 1 expression via ERK signaling.I examined the relationship between p63 and sonic hedgehog. I overexpressed p63 in keratinocyte and showed the promoter activity of sonic hedgehog increased. In vivo, I showed that p63 expressed strongly in basal cell carcinoma by immunostaining method.
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