2009 Fiscal Year Final Research Report
Development of novel melanoma marker using tumor specific DNA methylation
Project/Area Number |
20790787
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Dermatology
|
Research Institution | University of Tsukuba |
Principal Investigator |
FURUTA Junichi University of Tsukuba, 大学院・人間総合科学研究科, 講師 (30436274)
|
Project Period (FY) |
2008 – 2009
|
Keywords | 癌 / エピジェネティクス / 悪性黒色腫 / DNAメチル化 / 腫瘍マーカー |
Research Abstract |
We aimed to find the seeds for melanoma molecular marker using melanoma specific DNA methylation. The methylation of RASSF1A was detected in 20% of melanocyitic nevus specimens, whereas in 36% of malignant melanoma specimens. These result suggest that ras signaling pathway including RASSF1 plays an important role in melanocyitic tumors regardless malignant or benign.
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Research Products
(3 results)