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2009 Fiscal Year Final Research Report

The effect of B cell depletion on humoral responses during anit-CD20 mAb immunotherapy

Research Project

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Project/Area Number 20790790
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionKanazawa University

Principal Investigator

HAMAGUCHI Yasuhito  Kanazawa University, 附属病院, 講師 (60420329)

Project Period (FY) 2008 – 2009
KeywordsB細胞 / CD20 / 免疫応答
Research Abstract

The full effects of B cell depletion on humoral immunity are largely unknown. To address this issue, mature B cells were depleted in mice using CD20 mAb. CD20^+ B cell depletion prevented humoral immune responses and class switching, and depleted B cell memory. Nonetheless, B cell depletion did not affect serum Ig levels, Ag-specific antibody titers, or bone marrow antibody-secreting plasma cell numbers. Thus, depleting mature and memory B cells does not have a dramatic negative effect on pre-existing antibody levels.

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Published: 2011-06-18   Modified: 2016-04-21  

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