2009 Fiscal Year Final Research Report
Analysis of lipid metabolic pathway activated by ganglioside in human melanoma cells and its application to melanoma therapy
| Project/Area Number |
20790796
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
YAMAUCHI Yoshio Nagoya University, 大学院・医学系研究科, 助教 (00444878)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | メラノーマ / ガングリオシド / 脂質代謝 / Aktシグナル |
|---|
| Research Abstract |
Plasma membrane microdomains plays crucial roles in malignant properties of various cancer cells. Metabolism of cholesterol, an essential component of the microdomains, and its role in malignant phenotype of melanoma cells were investigated. The results show that Akt signaling serves as a molecular switch to
|
-
[Journal Article] GM1/GD1b/GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line.2010
Author(s)
Dong Y., Ikeda K., Hamamura K., Zhang Q., Kondo Y., Matsumoto Y., Ohmi Y., Yamauchi Y., Furukawa K., Taguchi R., Furukawa K.
-
Journal Title
Peer Reviewed
-
-
-
-
-
-
