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2009 Fiscal Year Final Research Report

Analysis of lipid metabolic pathway activated by ganglioside in human melanoma cells and its application to melanoma therapy

Research Project

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Project/Area Number 20790796
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionNagoya University

Principal Investigator

YAMAUCHI Yoshio  Nagoya University, 大学院・医学系研究科, 助教 (00444878)

Project Period (FY) 2008 – 2009
Keywordsメラノーマ / ガングリオシド / 脂質代謝 / Aktシグナル
Research Abstract

Plasma membrane microdomains plays crucial roles in malignant properties of various cancer cells. Metabolism of cholesterol, an essential component of the microdomains, and its role in malignant phenotype of melanoma cells were investigated. The results show that Akt signaling serves as a molecular switch to

  • Research Products

    (7 results)

All 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] GM1/GD1b/GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line.2010

    • Author(s)
      Dong Y., Ikeda K., Hamamura K., Zhang Q., Kondo Y., Matsumoto Y., Ohmi Y., Yamauchi Y., Furukawa K., Taguchi R., Furukawa K.
    • Journal Title

      (in press)

    • Peer Reviewed
  • [Journal Article] 脂質ラフトを介するシグナル制御と糖脂質糖鎖機能2008

    • Author(s)
      古川鋼一、山内祥生、章青、大海雄介、古川圭子
    • Journal Title

      日本内分泌学会雑誌 84

      Pages: 147

  • [Presentation] Role of SREBP pathway in Akt signaling in human melanoma cells2009

    • Author(s)
      山内祥生、古川圭子、古川鋼一
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      20091000
  • [Presentation] ヒトメラノーマ細胞においてSREBP経路はAktシグナルによって制御されている2009

    • Author(s)
      山内祥生、古川圭子、古川鋼一
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      20091000
  • [Presentation] Ganglioside GD3-dependent Akt signaling leads to activation of SREBP to regulate lipogenesis in human melanoma cells2008

    • Author(s)
      山内祥生、渡邊夕樹、宮崎清香、古川圭子、古川鋼一
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20081200
  • [Presentation] ヒトメラノーマ細胞においてガングリオシドGD3はAktシグナルを介してSREBPを活性化する2008

    • Author(s)
      山内祥生、渡邊夕樹、宮崎清香、古川圭子、古川鋼一
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      20081000
  • [Presentation] 脂質ラフトを介するシグナル制御と糖脂質糖鎖2008

    • Author(s)
      古川鋼一、山内祥生、浜村和紀、章青、大海雄介、愛新覚羅維、古川圭子
    • Organizer
      第81回日本内分泌学会学術総会
    • Place of Presentation
      青森
    • Year and Date
      20080500

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Published: 2011-06-18   Modified: 2016-04-21  

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