2009 Fiscal Year Final Research Report
A role of nuclear import activity on the pathomechanism of cutaneous diseases
| Project/Area Number |
20790800
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Osaka University |
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Principal Investigator |
UMEGAKI Noriko Osaka University, 医学系研究科, 助教 (80397629)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 核移行シグナル / karyopherin α2 / TAP methods / mass spectrometry |
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| Research Abstract |
Detection and analysis of target proteins imported by karyopherin alpha 2 (KPNA2) in HaCaT cells using tandem affinity purification method and mass spectrometry to investigate the roles of KPNA2 in the cell growth. Immunohistochemical staining using anti-KPNA2 antibody was performed in the skin diseases including psoriasis and squamous cell carcinomas to demonstrate the relation ship between KPNA2 and keratinocyte proliferation.
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[Journal Article] Novel and recurrent nonsense mutation of the SLC39A4 gene in Japanese patients with acrodermatitis enteropathica2009
Author(s)
Nakano H, Nakamura Y, Kawamura T, Shibagaki N, Matsue H, Aizu T, Rokunohe D, Akasaka E, Kimura K, Nishizawa A, Umegaki N, Mitsuhashi Y, Shimada S, Sawamura D.
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Journal Title
Br J Dermatol 161(1)
Pages: 184-6
Peer Reviewed
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