2009 Fiscal Year Final Research Report
The role of extracellular matrix protein in the pathogenesis of atopic dermatitis
| Project/Area Number |
20790806
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Saga University |
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Principal Investigator |
SHIRAISHI Hiroshi Saga University, 医学部, 助教 (80452837)
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| Project Period (FY) |
2008 – 2009
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| Keywords | アレルギー / アトピー性皮膚炎 / periostin Th2 |
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| Research Abstract |
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier impairment and immunologic abnormalities, in which Th2 type responses dominate; however the underlying mechanism remains unclear. In this study, we identified an extracellular matrix protein, periostin, which plays an important role in the pathogenesis of AD.
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[Journal Article] Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness.2009
Author(s)
Ito T, Suzuki S, Kanaji S, Shiraishi H, Ohta S, Arima K, Tanaka G, Tamada T, Honjo E, Garcia KC, Kuroki R, Izuhara K
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Journal Title
J Biol Chem 284
Pages: 24289-96
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[Journal Article]2009
Author(s)
Izuhara K, Ohta S, Shiraishi H, Suzuki S, Taniguchi K, Toda S, Tanabe T, Yasuo M, Kubo K, Hoshino T, Aizawa H
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Journal Title
Curr Med Chem 16
Pages: 2867-75
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[Presentation] Periostin plays an important role in the pathogenesis of pulmonary fibrosis.2009
Author(s)
Uchida M, Ohta S, Shiraishi H, Ohshima K, Okamoto M, Hoshino T, Aizawa H, Conway SJ, Izuhara K
Organizer
Allergy and Asthma, Fibrosis Keystone Symposia
Place of Presentation
Keystone, Colorado
Year and Date
2009-01-23
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