2009 Fiscal Year Final Research Report
Investigation of antipruritic effects in atopic dermatitis using nerve repulsion factor Sema3A
| Project/Area Number |
20790818
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Juntendo University |
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Principal Investigator |
TOMINAGA Mitsutoshi Juntendo University, 大学院・医学研究科, 博士研究員 (50468592)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 痒み / アトピー性皮膚炎 / Semaphorin 3A / 知覚神経 |
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| Research Abstract |
This study was performed to investigate antipruritic effects of semaphorin 3A (Sema3A), which is one of nerve repulsion factors, in atopic dermatitis (AD) using NC/Nga mouse, an AD model. Topical application of recombinant human Sema3A ointment on atopic NC/Nga mice significantly suppressed the scratching behavior and dermatitis compared with those of control mice. Therefore, this finding suggested the therapeutic efficacy of Sema3A ointment in pruritus and dermatitis of AD.
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