2009 Fiscal Year Final Research Report
Establishment and pathological analysis of novel white spot model mice
| Project/Area Number |
20790821
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Chubu University |
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Principal Investigator |
KUMASAKA Mayuko Chubu University, 生命健康科学研究所, 研究員 (90469023)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 白斑症 / モデルマウス / 色素細胞 |
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| Research Abstract |
ss-catenin is associated with white spotting induced by abnormal migration of melanoblasts and melanocytes. Among ECMs, fibronectin is suggested to be involved in this phenotype. On fibronectin, melanocytes from the white spot model mice migrate slower than those from wild-type mice. Changes of orientation of F-actin and the associated signaling in this white spot mice are responsible for this phenotype.
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