Study of the mechanism of the effect of electro convulsive therapy on a treatment-resistant animal model in schizophrenia

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790826
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Hokkaido University
• Principal Investigator: ITOH Kohki Hokkaido University, 大学院・医学研究科, 助教 (40455663)
• Project Period (FY): 2008 – 2009
• Keywords: 統合失調症 / 精神刺激薬動物モデル / 電気痙攣療法 / プレパルスインヒビション

Research Abstract

This study tested, using a psychostimulant animal model, called longitudinal progressive model and treatment responsive model, and an NMDA receptor antagonist model, called transactional model and treatment resistant model in schizophrenia, the effect of electro convulsive therapy(ECT). The present study showed that ECT had effects to prevent these drugs-induced behavioral and histological changes, suggesting that ECT might block the progressive pathophysiology in schizophrenia.