2009 Fiscal Year Final Research Report
Chronotherapy to mood disorders and It's mechanism
| Project/Area Number |
20790828
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Akita University |
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Principal Investigator |
ECHIZENYA Masaru Akita University, 医学部, 講師 (60420056)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 精神生理学 |
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| Research Abstract |
Sleep deprivation induces a rapid amelioration of mood in about 60% of depressed patients. After the next night of sleep, however, most patients experience a relapse. Previous studies demonstrated that some interventions could prevent a relapse. In this study, we tried total sleep deprivation followed by sleep phase advance and bright light therapy to drug-resistant depression. Treatment effects were evaluated by HAM-D (17 items and 6 items), SDS, VAS and SF-36. Twelve depressive patients (Unipolar/Bipolar=9/3) were treated in this protocol. According to the results, significant improvements were observed in HAM-D (17 items and 6 items), SDS, VAS and SF-36. Combined treatments in this study can be expected as clinically beneficial because drug-resistant patients improved in several days.
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