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2010 Fiscal Year Final Research Report

Explore of schizophrenia susceptible genes based on the findings in postmortem study

Research Project

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Project/Area Number 20790838
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionKobe University

Principal Investigator

FUKUTAKE Masaaki  Kobe University, 大学院・医学研究科, 助教 (80457085)

Project Period (FY) 2008 – 2010
Keywords統合失調症 / 自殺 / 相関研究 / 遺伝子多型 / SNP / ハプロタイプ
Research Abstract

Focusing on the biological vulnerability on which the pathogenesis of schizophrenia have been considered to be based, we have explored the genetic variants of schizophrenia susceptible genes. We have conducted association analysis of the interest genetic varints with schizophrenia based on the hypothesis such as the neurodevelopment model of schizophrenia. In addition, we have approached the subject from another perspective to identify the novel schizophrenia susceptible genetic variants using DNA microarray experiments to the postmortem study of schizophrenia, and based on the findings of the microarray analysis, we have conducted further association analysis. As a result, we have identified several important genetic variants associated with schizophrenia.

  • Research Products

    (19 results)

All 2011 2010 2009 2008

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Association of FKBP5 gene haplotypes with completed suicide in the Japanese population.2011

    • Author(s)
      Supriyanto I, Sasada T, Fukutake M, Asano M, Ueno Y, Nagasaki Y, Shirakawa O, Hishimoto A.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 35(1)

      Pages: 252-6

    • Peer Reviewed
  • [Journal Article] Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population.2011

    • Author(s)
      Kyogoku C, Yanagi M, Nishimura K, Sugiyama D, Morinobu A, Fukutake M, Maeda K, Shirakawa O, Kuno T, Kumagai S.
    • Journal Title

      Psychiatry Res. 185(1-2)

      Pages: 16-9

    • Peer Reviewed
  • [Journal Article] Association study of EP1 gene polymorphisms with suicide completers in the Japanese population.2010

    • Author(s)
      Cui H, Supriyanto I, Sasada T, Shiroiwa K, Fukutake M, Shirakawa O, Asano M, Ueno Y, Nagasaki Y, Hishimoto A.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. [Epub ahead of print]

    • Peer Reviewed
  • [Journal Article] Association study of RGS2 gene polymorphisms with panic disorder in Japanese.2010

    • Author(s)
      Mouri K, Hishimoto A, Fukutake M, Nishiguchi N, Shirakawa O, Maeda K.
    • Journal Title

      Kobe J Med Sci. 55(5)

      Pages: E116-21

    • Peer Reviewed
  • [Journal Article] A putative cis-acting polymorphism in the NOS1 gene is associated with schizophrenia and NOS1 immunoreactivity in the postmortem brain.2010

    • Author(s)
      Cui H, Nishiguchi N, Yanagi M, Fukutake M, Mouri K, Kitamura N, Hashimoto T, Shirakawa O, Hishimoto A.
    • Journal Title

      Schizophr Res. 121(1-3)

      Pages: 172-8

    • Peer Reviewed
  • [Journal Article] Common genetic variations in TPH1/TPH2 genes are not associated with schizophrenia in Japanese population.2010

    • Author(s)
      Shiroiwa K, Hishimoto A, Mouri K, Fukutake M, Supriyanto I, Nishiguchi N, Shirakawa O.
    • Journal Title

      Neurosci Lett. 472(3)

      Pages: 194-8

    • Peer Reviewed
  • [Journal Article] Alcohol and aldehyde dehydrogenase polymorphisms and risk for suicide : a preliminary observation in the Japanese male population.2010

    • Author(s)
      Hishimoto A, Fukutake M, Mouri K, Nagasaki Y, Asano M, Ueno Y, Nishiguchi N, Shirakawa O.
    • Journal Title

      Genes Brain Behav 9(5)

      Pages: 498-502

    • Peer Reviewed
  • [Journal Article] 生物学的視点からみた自殺2010

    • Author(s)
      福武将映、白川治
    • Journal Title

      自殺予防と危機介入 第30巻第1号

      Pages: 84-91

    • Peer Reviewed
  • [Journal Article] TPH2 is not a susceptibility gene for suicide in Japanese population.2009

    • Author(s)
      Mouri K, Hishimoto A, Fukutake M, Shiroiwa K, Asano M, Nagasaki Y, Ueno Y, Shirakawa O, Nishiguchi N, Maeda K.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 33(8)

      Pages: 1546-50

    • Peer Reviewed
  • [Journal Article] Scale for measuring self-recoverability in daily life for people with schizophrenia.2009

    • Author(s)
      Takamatsu T, Hashimoto T, Taira M, Fukutake M, Maeda K.
    • Journal Title

      Psychiatry Clin Neurosci. 63(3)

      Pages: 277-82

    • Peer Reviewed
  • [Journal Article] 精神科外来における統合失調症患者に対するblonanserinの使用経験2009

    • Author(s)
      菱本明豊、福武将映、山本泰司、毛利健太朗、白岩恭一、田中究、青山慎介、前田潔
    • Journal Title

      臨床精神薬理 12(9)

      Pages: 1999-2009

    • Peer Reviewed
  • [Journal Article] Association of alpha2A-adrenergic receptor gene polymorphism with susceptibility to suicide in Japanese females.2008

    • Author(s)
      Fukutake M, Hishimoto A, Nishiguchi N, Nushida H, Ueno Y, Shirakawa O, Maeda K.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 32(6)

      Pages: 1428-33

    • Peer Reviewed
  • [Journal Article] Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia.2008

    • Author(s)
      Yanagi M, Hashimoto T, Kitamura N, Fukutake M, Komure O, Nishiguchi N, Kawamata T, Maeda K, Shirakawa O.
    • Journal Title

      Schizophr Res. 100(1-3)

      Pages: 291-301

    • Peer Reviewed
  • [Journal Article] Association of RGS2 gene polymorphisms with suicide and increased RGS2 immunoreactivity in the postmortem brain of suicide victims.2008

    • Author(s)
      Cui H, Nishiguchi N, Ivleva E, Yanagi M, Fukutake M, Nushida H, Ueno Y, Kitamura N, Maeda K, Shirakawa O.
    • Journal Title

      Neuropsychopharmacology 33(7)

      Pages: 1537-44

    • Peer Reviewed
  • [Presentation] Association of FKBP5 gene haplotypes with completed suicide in the Japanese population.2011

    • Author(s)
      Hishimoto A, Sasada T, Fukutake M, Shiroiwa K, Supriyanto I, Shirakawa O.
    • Organizer
      The 18th European Congress of Psychiatry
    • Place of Presentation
      Vienna(Austria)
    • Year and Date
      2011-03-15
  • [Presentation] 神経型一酸化窒素合成酵素(NOS1)遺伝子のシス活性を持つ一塩基多型は死後脳NOS1免疫反応レベルと統合失調症に相関する2010

    • Author(s)
      菱本明豊、福武将映, 他
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      小倉
    • Year and Date
      2010-10-08
  • [Presentation] 精神科外来における統合失調症患者に対するblonanserinの使用経験2009

    • Author(s)
      福武将映, その他
    • Organizer
      第19回日本臨床精神神経薬理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-13
  • [Presentation] RGS2遺伝子多型とパニック障害との相関研究2009

    • Author(s)
      毛利健太朗、福武将映, 他
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-25
  • [Book] 専門医のための精神科臨床リュミエール29自殺予防の基本戦略III2011

    • Author(s)
      福武将映、菱本明豊、白川治、中山書店
    • Total Pages
      24-34
    • Publisher
      自殺の生物学的知見

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Published: 2012-02-13   Modified: 2016-04-21  

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