2009 Fiscal Year Final Research Report
Disrupted in Schizophrenia-1 (Disc-1), a candidate gene of schizophrenia regulates kalirin and maintains synapse.
| Project/Area Number |
20790840
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Okayama University |
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Principal Investigator |
TAKAKI Manabu Okayama University, 岡山大学病院, 助教 (60452570)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 統合失調症 / DISC-1 / カリリン / シナプス / セントロソーム / PCM-1 / BBS4 |
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| Research Abstract |
Disrupted in Schizophrenia-1 (Disc-1) is a candidate gene of schizophrenia. Following to the development, Disc-1, dynein and BBS4, the binding protein of Disc-1 moved from centrosome to spine. On the other hand, r-tubulin and PCM-1 did not. Disc-1 regulates kalirin and maintains spine. Disc-1 inhibited the binding of Kalirin-7 and Rac1. Clozapine, one of the atypical psychotics, which is effective to intractable schizophrenia and related to NMDA receptor function, increased PSD95, a post synaptic marker.
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