Mathematics and computational analysis of brain structural MRI and application to psychiatric diseases

2010 Fiscal Year Final Research Report

• Project/Area Number: 20790846
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: UENO Takefumi Kyushu University, 保健医療学部, 准教授 (00441668)
• Research Collaborator: KANBA Shigenobu 九州大学, 大学院・医学研究院・精神病態医学, 教授 (50195187) ; ONITSUKA Toshiaki 九州大学大学, 大学病院, 講師 (00398059) ; 古田 歩 , 前田眼科, 医師
• Project Period (FY): 2008 – 2010
• Keywords: MRI / 脳 / 数学 / 画像処理 / 統計 / 精神疾患 / 統合失調症 / 気分障害

Research Abstract

Recently brain imaging studies using magnetic resonance imaging (MRI) were often reported in the psychiatry research. This study was aimed to apply an mathematical theory to the brain imaging study to understand the structural brain anatomy in psychiatric patients more simply and more accurately. We used differential geometry theories to segment the brain anatomical structure. Computational programs were written using differential geometry. Then we collected MRI imaging in psychiatric patients i.e. schizophrenia affective disorder and seizure. Using differential geometry method we compared intracranial volumes. However significant difference were not detected so far. By collecting MRI images and detecting the differences we can try to cutting edge of the psychiatric disorders in the future.

Research Products

• [Journal Article] Comparison between real sequential finger and imagery movements : an fMRI study revisited (2010)
  • Author(s): Takefumi Ueno, Masayuki Inoue, Kiichiro Morita, Toshihiko Matsuoka, Toshi Abe, Hisao Maeda
  • Journal Title: Brain Imaging and Behavior 4 Pages: 80-85
  • Peer Reviewed
• [Journal Article] Developmental changes in multivariate neuroanatomical patterns that predict risk for psychosis in 22q11.2 deletion syndrome. (2010)
  • Author(s): Gothelf D, Hoeft F, Ueno T, Sugiura L, Lee AD, Thompson P, Reiss AL.
  • Journal Title: Psychiatr Res.
  • Peer Reviewed
• [Journal Article] Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds : a MEG study. (2010)
  • Author(s): Oribe N, Onitsuka T, Hirano S, Hirano Y, Maekawa T, Obayashi C, Kasai K, Ueno T, Kanba S
  • Journal Title: Bipolar Disord. 12 Pages: 804-812
  • Peer Reviewed
• [Journal Article] Locked to the stimulation ; significance level of the phase locking factor (2009)
  • Author(s): Takefumi Ueno, Shogo Hirano, Yoji Hirano, Shigenobu Kanba, Shinji Kobayashi, Toshiaki Onitsuka
  • Journal Title: Proc.Cong.Image and Signal Processing IEEE 8 Pages: 4448-4451
  • Peer Reviewed
• [Journal Article] Brain Activities on fMRI Using the shiritori Task in Normal Subjects : Kurume
  • Author(s): Masayuki Inoue, Takefumi Ueno, Kiichiro Morita, Yoshihisa Shoji, Toshimasa Matsuoka, Ryo Fujiki, Toshi Abe, Naohisa Uchimura
  • Journal Title: Med J (in press)
  • Peer Reviewed
• [Presentation] Characteristics of the brain function related to a simple motor task in schizophrenia patients (2010)
  • Author(s): Ueno T, Inoue M, Fujiki R, Morita K
  • Organizer: Society for Nueroscience, Convention Center
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-14
• [Presentation] Locked to Stimulation : Significance Level of the Phase-Locking Factor (2009)
  • Author(s): Takefumi Ueno, Shogo Hirano, Yoji Hirano, Shigenobu Kanba, Shinji Kobayashi, Toshiaki Onitsuka
  • Organizer: 2nd International Congress on Image and Signal Processing
  • Place of Presentation: Saixiang Hotel, Tianjin, China
  • Year and Date: 2009-10-17
• [Presentation] A trial of skull stripping with intensity and mathamatical estimation (2009)
  • Author(s): T Ueno, R Fukushima, A Furuta, S Hirano, N Oribe, C Ohbayashi, Y Hirano, T Maekawa, R Tsuchimoto, S Kanba, T Onitsuka
  • Organizer: Annual Meeting of OHBM 2009, NeuroImage, Volume 47, Supplement 1, Pages S39-S41
  • Place of Presentation: Marriot Hotel, San Francisco
  • Year and Date: 2009-06-21
• [Presentation] VBMにおけるsmoothing kernelの違いについて (2009)
  • Author(s): 上野雄文
  • Organizer: MRIワーキンググループ
  • Place of Presentation: 東京大学、東京都
  • Year and Date: 2009-06-13
• [Presentation] 頭部MRI画像の組織分離の試み (2009)
  • Author(s): 上野雄文
  • Organizer: 生物学的精神医学会
  • Place of Presentation: 国立京都国際会館、京都府
  • Year and Date: 2009-04-24
• [Book] 精神科医のための脳科学(機能的MRIと精神疾患、専門医のための精神科臨床リュミエール、16巻) (2010)
  • Author(s): 上野雄文
  • Total Pages: 260-262
  • Publisher: 中山書店、東京都