Possibility of autologous cell transplantation therapy

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790850
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Sapporo Medical University
• Principal Investigator: ONO Takafumi Sapporo Medical University, 医学部, 研究員 (50438024)
• Project Period (FY): 2008 – 2009
• Keywords: 精神薬理学

Research Abstract

We have suggested that the intravenous transplantation of neural stem cells could recover the negative symptom and cognitive dysfunction in the schizophrenic animal model. The exogenous neural stem cells have shown the neuroprotective effect and the promotive effect of neurogenesis, and the change of Akt and ERK activation may be concerned with the mechanism of the neuroprotective effect.

Research Products

• [Journal Article] 非定型抗精神病薬の神経新生作用 (2009)
  • Author(s): 橋本恵理, 鵜飼渉, 小野貴文, 齋藤利和
  • Journal Title: 脳21 12巻 Pages: 95-199
  • Peer Reviewed
• [Journal Article] 気分障害における神経回路網の修復再生と認知機能 (2009)
  • Author(s): 鵜飼渉, 橋本恵理, 石井貴男, 吉永敏弘, 渡邊公彦, 小野貴文, 館農勝, 渡邉一平, 白坂智彦, 齋藤利和
  • Journal Title: 臨床精神医学 38巻 Pages: 421-428
  • Peer Reviewed
• [Journal Article] The role of neural stem cells for in vitro models of schizophrenia: neuroprotection via Akt/ERK signal regulation.
  • Author(s): Ono T, Hashimoto E, Ukai W, Ishii T, Saito T
  • Journal Title: Schizophrenia Research (in press)
  • Peer Reviewed
• [Presentation] Stem cell therapy as a new treatment strategy for schizophnia. (2009)
  • Author(s): Ukai W
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago
  • Year and Date: 2009-10-18
• [Presentation] 神経幹細胞移植は統合失調症の慢性期症状を抑制する (2009)
  • Author(s): 小野貴文
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 京都
  • Year and Date: 2009-04-25
• [Presentation] Altered trophic factor signaling in the mechanism of neuroprotection by exogenous neural stem cells. (2008)
  • Author(s): Ono T
  • Organizer: Neuroscience 2008
  • Place of Presentation: Washington, DC
  • Year and Date: 2008-11-19
• [Presentation] アルコール性精神障害に対する神経幹細胞移植療法の可能性に関する検討. 第20回日本アルコール精神医学会 (2008)
  • Author(s): 小野貴文
  • Organizer: 第11回ニコチン・薬物依存研究フォーラム平成20年度合同学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-16
• [Presentation] The effect of exogenous neural stem cell against the damaged neurons and neural stem cells. (2008)
  • Author(s): 小野貴文
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-12