The common points between the pathology of depression and platelet release factor

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790851
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Sapporo Medical University
• Principal Investigator: WATANABE Kimihiko Sapporo Medical University, 医学部, 研究員 (70464493)
• Project Period (FY): 2008 – 2009
• Keywords: 脳・神経 / 神経科学 / うつ病 / 血小板 / BDNF / 神経幹細胞 / 神経新生

Research Abstract

Brain-derived neurotrophic factor (BDNF) exists in peripheral tissues and is mainly stored in platelets and circulates in blood. Recent reports indicate that serum BDNF levels in depressive patients are lower than in control subjects, and antidepressant treatment increases serum BDNF levels in responders. In the present study, we investigated the direct influence of antidepressants on BDNF release from platelets and their effects on serum levels. These results confirm that BDNF release from platelets is affected by antidepressants, which may relate to the circulating BDNF level change in peripheral blood. The response of BDNF release differs depending on the type and amount of antidepressants, making BDNF a serious candidate as a predictor of antidepressant treatment response.

Research Products

• [Journal Article] Low serum BDNF and food intake regulation: A possible new explanation of the pathophysiology of eating disorders. (2009)
  • Author(s): Saito S, Watanabe K, Hashimoto E, Saito T
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 33(2) Pages: 312-6
  • Peer Reviewed
• [Journal Article] 気分障害における神経回路網の修復再生と認知機能 (2009)
  • Author(s): 鵜飼渉, 橋本恵理, 石井貴男, 吉永敏弘, 渡邊公彦, 小野貴文, 館農勝, 渡邉一平, 白坂知彦, 齋藤利和
  • Journal Title: 臨床精神医学 38 Pages: 421-428
• [Journal Article] 神経新生と病態「向精神薬」 (2008)
  • Author(s): 橋本恵理小野貴文渡邊公彦
  • Journal Title: 臨床神経科学 26巻8号 Pages: 887-889
• [Journal Article] Effect of antidepressants
  • Author(s): Kimihiko Watanabe, Eri Hashimoto, Wataru Ukai, Takao Ishii, Toshihiro Yoshinaga, Takafumi Ono, Masaru Tateno, Ippei Watanabe, Tomohiro Shirasaka, Satoshi Saito, Toshikazu Saito
  • Journal Title: on brain-derived neurotrophic factor (BDNF) release from platelets (in press)
  • Peer Reviewed
• [Presentation] うつ病モデルラットにおける末梢血BDNF変化-血小板BDNF遊離の観点から- (2009)
  • Author(s): 渡邊公彦、鵜飼渉、石井貴男、吉永敏弘、小野貴文、渡邉一平、白坂知彦、館農勝、橋本恵理、齋藤利和
  • Organizer: 第28回躁うつ病の薬理・生化学的研究懇話会
  • Place of Presentation: 千歳市
  • Year and Date: 20090710-20090711
• [Presentation] うつ病における血小板BDNFの働き (2009)
  • Author(s): 渡邊公彦、橋本恵理、鵜飼渉、石井貴男、吉永敏弘、小野貴文、館農勝、渡邉一平、白坂知彦、齋藤利和
  • Organizer: 第52回日本神経化学会
  • Place of Presentation: 群馬
  • Year and Date: 2009-06-22
• [Presentation] うつ病治療のオーダーメイド化を目指して-末梢血BDNF量変化について- (2008)
  • Author(s): 渡邊公彦、鵜飼渉、橋本恵理、石井貴男、吉永敏弘、小野貴文、渡邉一平、白坂知彦、館農勝、齋藤諭、齋藤利和
  • Organizer: 第28回日本精神科診断学会
  • Place of Presentation: 札幌
  • Year and Date: 20081010-20081011
• [Presentation] Brain-derived neurotrophic factor in platelets is released by antidepressants. (2008)
  • Author(s): Watanabe K, Ukai W, Hashimoto E, Yoshinaga T, Ishii T, Tateno M, Ono T, Watanabe I, Shirasaka T, Saito S, Saito T
  • Organizer: 2nd WFSBP Asia pacific Congress Sep 11-13 Toyama
  • Place of Presentation: Japan
  • Year and Date: 20080911-20080913
• [Presentation] The influence of antidepressants on the neurotrophic factors in platelets. (2008)
  • Author(s): Watanabe K, Ukai W, Hashimoto E, Yoshinaga T, Ishii T, Tateno M, Ono T, Watanabe I, Shirasaka T, Saito S, Saito T
  • Organizer: The 11th Congress of the ASEAN Federation for Psychiatry and Mental Health (AFPMH)
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 20080826-20080829
• [Presentation] 抗うつ薬による末梢血BDNF量変化に関する検討 (2008)
  • Author(s): 渡邊公彦、鵜飼渉、石井貴男、吉永敏弘、小野貴文、渡邉一平、白坂知彦、館農勝、橋本恵理、齋藤諭、齋藤利和
  • Organizer: 第27回躁うつ病の薬理・生化学的研究懇話会
  • Place of Presentation: 箱根
  • Year and Date: 2008-06-20