2009 Fiscal Year Final Research Report
A study on the pathophysiology of dementia with Lewy bodies (DLB) and the usefulness of Yokukan-san for the treatment of DLB and its functional mechanism
| Project/Area Number |
20790852
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
TATENO Masaru Sapporo Medical University, 医学部, 講師 (60464492)
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| Project Period (FY) |
2008 – 2009
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| Keywords | レビー小体型認知症 / レビー小体病 / アルツハイマー病 / アミロイドβ蛋白 / 抑肝散 / 脳血流SPECT / MIBG心筋シンチグラフィー / 細胞障害 |
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| Research Abstract |
We examined the usefulness of statistical analysis programs of brain perfusion SPECT for the clinical diagnosis of dementia with Lewy bodies (DLB) and demonstrated the relation between occipital hypoperfusion and Parkinsonism, and orthostatic hypotension and the heart-to-mediastinum (H/M) ratio on MIBG myocardial scintigraphy. These results suggest that autonomic dysfunction plays an important role in the pathophysiology of DLB. In vitro study using primary culture of rat cortical neuron indicated that Yokukan-san had neuroprotective effect against beta amyloid protein (Aβ)-induced cytotoxicity.
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