Behavioral physiological and molecular biological analyses of animal model for bipolar disorder

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790864
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: KASAHARA Takaoki The Institute of Physical and Chemical Research, 精神疾患動態研究チーム, 副チームリーダー (50344031)
• Project Period (FY): 2008 – 2009
• Keywords: 双極性障害 / 動物モデル / Polg1 / Wfs1 / メラトニン / リチウム

Research Abstract

I analyzed wheel-running activity of an animal model for bipolar disorder, mutant Polg1 transgenic mice, for more than a half year. This shed light on the pathophysiology involving the seasonality or photoperiodicity. I obtained novel findings on melatonin synthesis of mice. In addition, I succeeded in treating mice with lithium, a mood stabilizer, more than three months without affecting health of mice. Using the method of lithium treatment, I investigated the effect of lithium on the longitudinal manifestations of the model mice.

Research Products

• [Journal Article] 加藤忠史双極性障害モデル実験動物. (2010)
  • Author(s): 笠原和起
  • Journal Title: 生体の科学 64 Pages: 59-64
• [Journal Article] Genetic variation of melatonin productivity in laboratory mice under domestication. (2010)
  • Author(s): Kasahara, T., Abe, K., Mekada, K., Yoshiki, A., Kato, T.
  • Journal Title: Proc. Natl. Acad. Sci. USA. 107 Pages: 6412-6417
  • Peer Reviewed
• [Journal Article] Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder. (2009)
  • Author(s): Hayashi, A., Kasahara, T., Kametani, M., Toyota, T., Yoshikawa, T., Kato, T.
  • Journal Title: Int. J. Neuropsychopharmacol. 12 Pages: 33-43
  • Peer Reviewed
• [Journal Article] Attenuated BDNF-induced upregulation of GABAergic markers in neurons lacking Xbp1. (2008)
  • Author(s): Hayashi, A., Kasahara, T., Kametani, M., Kato, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 376 Pages: 758-763
  • Peer Reviewed
• [Journal Article] A marked effect of electroconvulsive stimulation on behavioral aberration of mice with neuron-specific mitochondrial DNA defects. (2008)
  • Author(s): Kasahara, T., Kubota, M., Miyauchi, T., Ishiwata, M., Kato T.
  • Journal Title: PLoS ONE 3 Pages: 1877
  • Peer Reviewed
• [Journal Article] Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder. (2008)
  • Author(s): Kato, T., Ishiwata, M., Yamada, K., Kasahara T., Kakiuchi, C., Iwamoto, K., Kawamura, K., Ishihara, H., Oka, Y.
  • Journal Title: Neurosci. Res. 61 Pages: 143-153
  • Peer Reviewed
• [Journal Article] PQQビタミン説へのアプローチ. (2008)
  • Author(s): 野地なつ美, 笠原和起, 浅見忠男
  • Journal Title: 化学と生物 46 Pages: 339-345
• [Journal Article] 双極性障害におけるミトコンドリア機能障害. (2008)
  • Author(s): 笠原和起, 加藤忠史
  • Journal Title: 脳と精神の医学 19 Pages: 107-115
• [Journal Article] Therapeutic implications of down-regulation of cyclophilin D in bipolar disorder.
  • Author(s): Kubota, M., Kasahara, T., Iwamoto, K., Komori, A., Ishiwata, M., Miyauchi, T., Kato, T.
  • Journal Title: Int. J. Neuropsychopharmacol. (in press)
  • Peer Reviewed
• [Journal Article] 気分障害薬物療法の脳科学.
  • Author(s): 笠原和起
  • Journal Title: 精神科 (印刷中)
• [Presentation] Mouse models for bipolar disorder based on rare hereditary diseases. (2009)
  • Author(s): Kasahara, T.
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 20090900
• [Presentation] Identification of mouse HIOMT gene. (2009)
  • Author(s): Kasahara, T., Kato, T.
  • Organizer: Gordon Research Conference
  • Place of Presentation: ニューポート, 米国
  • Year and Date: 20090700
• [Presentation] マウスのメラトニン合成能の飼育舎内進化 (2009)
  • Author(s): 笠原和起, 阿部訓也, 加藤忠史
  • Organizer: 第23回モロシヌス研究会
  • Place of Presentation: 守山
  • Year and Date: 20090700
• [Presentation] 複数の遺伝的負因を持つ双極性障害モデルマウスの開発. (2009)
  • Author(s): 笠原和起, 石渡みずほ, 宮内妙子, 山田一之, 垣内千尋, 川村光毅, 石原寿光, 岡芳知, 加藤忠史
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 富山
  • Year and Date: 20090400
• [Presentation] Mitochondrial Dysfunction in Bipolar Disorder. (2008)
  • Author(s): Kasahara, T., Kato, T.
  • Organizer: 2nd World Federation of Societies of Biological Psychiatry Asia-Pacific Congress・第30回日本生物学的精神医学会
  • Place of Presentation: 富山
  • Year and Date: 20080900
• [Presentation] 双極性障害のミトコンドリア機能障害仮説に基づいたモデル動物が示す異常行動とそれに対する治療効果. (2008)
  • Author(s): 笠原和起, 窪田美恵, 宮内妙子, 石渡みずほ, 加藤忠史
  • Organizer: 第27回躁うつ病の薬理・生化学的研究懇話会
  • Place of Presentation: 箱根
  • Year and Date: 20080600
• [Presentation] Transgenic mice with neuron-specific mitochondrial DNA defects as a model for bipolar disorder. (2008)
  • Author(s): Kasahara, T., Kubota, M., Miyauchi, T., Ishiwata, M., Kato, T.
  • Organizer: Euromit7
  • Place of Presentation: ストックホルム, スウェーデン
  • Year and Date: 20080600
• [Book] 精神科臨床リュミエール
  • Author(s): 笠原和起
  • Total Pages: 16
  • Publisher: 中山書店