2009 Fiscal Year Final Research Report
Genetic analyses of FABP genes in functional psychoses
| Project/Area Number |
20790867
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YIWAYAMA Yoshimi The Institute of Physical and Chemical Research, 分子精神科学研究チーム, リサーチアソシエイト (60399441)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 統合失調症 / 双極性障害 / FABP遺伝子 / 不飽和脂肪酸 / 関連研究 / 死後脳発現解析 |
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| Research Abstract |
Deficits in prepulse inhibition (PPI) are a biological marker for psychiatric illnesses such as schizophrenia and bipolar disorder. To unravel PPI-controlling mechanisms, we previously performed quantitative trait loci analysis in mice, and identified Fabp7, that encodes a brain-type fatty acid binding protein (Fabp), as a causative gene. FABPs constitute a gene family, of which members FABP5 and FABP3 are also expressed in the brain. In this project, I examined the genetic roles of these FABP genes in schizophrenia and bipolar disorder. FABP7 showed nominal association with bipolar disorder (we previously reported an association of FABP7 with schizophrenia). We could not obtain evidence for associations of FABP5 and FABP3 with either disease.
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[Journal Article] Association analyses between brain-expressed FABP (fatty-acid binding protein) genes and schizophrenia and bipolar disorder.2010
Author(s)
Iwayama Y., Hattori E., Maekawa M., Yamada K., Toyota T., Ohnishi T., Iwata Y., Tsuchiya K., Sugihara G., Kikuchi M., Hashimoto K., Iyo M., Inada T., Kunugi H., Okazaki N., Iwata N., Nanko S., Iwamoto K., Okazaki Y., Kato T., Yoshikawa T.
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Journal Title
Am. J. Med. Genet. Part B. 153B
Pages: 484-493
Peer Reviewed
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[Journal Article] Polymorphism screening of brain-expressed FABPs7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects.2010
Author(s)
Maekawa M., Iwayama Y., Arai R., Nakamura K., Ohnishi T., Toyota T., Tsujii M., Okazaki Y., Osumi N., Owada Y., Mori N., Yoshikawa T.
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Journal Title
J. Hum. Genet. 55
Pages: 127-130
Peer Reviewed
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