2010 Fiscal Year Final Research Report
Polymorphism screening and association analysis of the plexin/semaphorin genes in neuropsychiatric diseases
| Project/Area Number |
20790870
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | National Center of Neurology and Psychiatry |
|---|
Principal Investigator |
FUJII Takashi National Center of Neurology and Psychiatry, 神経研究所・疾病研究第三部, 流動研究員 (10450610)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 臨床精神分子遺伝学 / Plexin / Semaphorin |
|---|
| Research Abstract |
Based on the neurodevelopmental hypothesis in the etiology of schizophrenia, the plexin/semaphorin genes might be involved in the pathogenesis of the illness. We searched for non-synonymous polymorphisms of these genes in silico based on the NCBI dbSNP database. Detected polymorphisms were subject to association analyses with neuropsychiatric diseases. In a series of studies, we found a significant association between the Lys701Gln polymorphism of SEMA3D and schizophrenia, genotyping a sample of 506 patients with schizophrenia and 941 healthy control subjects. The Gln701 allele showed a significant protective effect against the development of schizophrenia (p=0.0069). In addition, the haplotype rs2190208-rs1029564-rs17159614-rs121176601, not including the Lys701G1n variant, was shown to be associated with schizophrenia (p=0.00001), which suggests that some other polymorphisms of SEMA3D play a role in the pathogenesis of schizophrenia. Our findings provide strong evidence that SEMA3D confers susceptibility to schizophrenia, which could contribute to the neurodevelopmental impairments in the disorder.
|
-
-
-
[Journal Article] (* double first authors), Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease : New data and meta-analysis.
Author(s)
Fukumoto N, Fuiii T, Combarros O, Kamboh MI, Tsai SJ, Matsushita S, Nacmias B, Comings DE, Arboleda H, Ingelsson M, Hyman BT, Akatsu H, Grupe A, Nishimura AL, Zatz M, Mattila KM, Rinne J, Goto Y, Asada T, Nakamura S, Kunugi H.
-
-
-
-
-
-
-
-
[Remarks] ホームページ等
-
-
