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2009 Fiscal Year Final Research Report

Radiosensitization with molecular targeted drugs in pancreatic cancer therapy : analysis by tumor imaging

Research Project

  • PDF
Project/Area Number 20790892
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

ITASAKA Satoshi  Kyoto University, 医学研究科, 助教 (90378654)

Project Period (FY) 2008 – 2009
Keywords膵癌 / 放射線 / 分子標的 / イメージング / 低酸素
Research Abstract

Purpose of this study is to enhance the effects of irradiation on pancreatic cancer with molecular targeted drugs. We evaluated the treatment effects of radiation with anti-VEGF antibody and the change of HIF-1 activity by imaging. We confirmed that irradiation at the timing of low HIF-1 activity is correlated with enhanced irradiation effects. In contrast, when irradiation was given at the timing of high HIF-1 activity, anti-tumor effects of irradiation was decreased. We also revealed that newly developed hypoxia targeted drug achieves longer survival in orthotopic pancreatic cancer model.

  • Research Products

    (7 results)

All 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Book (1 results)

  • [Journal Article] The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors.2009

    • Author(s)
      Harada H, Itasaka S, Kizaka-Kondoh S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M
    • Journal Title

      J Biol Chem 284(8)

      Pages: 5332-5342

    • Peer Reviewed
  • [Journal Article] Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy.2009

    • Author(s)
      Harada H, Itasaka S, Zhu Y, Zeng L, Xie X, Morinibu A, Shinomiya K, Hiraoka M
    • Journal Title

      Br J Cancer. 100(5)

      Pages: 747-757

    • Peer Reviewed
  • [Journal Article] Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer.2009

    • Author(s)
      Kizaka-Kondoh S, Itasaka S, Zeng L, Tanaka S, Zhao T, Takahashi Y, Shibuya K, Hirota K, Semenza GL, Hiraoka M
    • Journal Title

      Clin Cancer Res. 15(10)

      Pages: 3433-3441

    • Peer Reviewed
  • [Journal Article] Usefulness of HIF-1 imaging for determining optimal timing of combining Bevacizumab and radiotherapy.2009

    • Author(s)
      Ou G, Itasaka S, Zeng L, Shibuya K, Yi J, Harada H, Hiraoka M
    • Journal Title

      Int J Radiat Oncol Biol Phys. 75(2)

      Pages: 463-467

    • Peer Reviewed
  • [Journal Article] Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors.2008

    • Author(s)
      Harada H, Xie X, Itasaka S, Zeng L, Zhu Y, Morinibu A, Shinomiya K, Hiraoka M.
    • Journal Title

      Biochem Biophys Res Commun. 373(4)

      Pages: 533-538

    • Peer Reviewed
  • [Journal Article] TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis.2008

    • Author(s)
      Zeng, L., Ou G, et al.. Zeng L, Ou G, Itasaka S, Harada H, Xie X, Shibuya K, Kizaka-Kondoh S, Morinibu A, Shinomiya K, Hiraoka M
    • Journal Title

      Cancer Sci 99(11)

      Pages: 2327-2335

    • Peer Reviewed
  • [Book] The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies Stratedies;Treatment of the Primary Tumor in Metastatic Cancer: Influence on Outcome.(Chapter 21)2009

    • Author(s)
      Itasaka S, Hiraoka M
    • Total Pages
      347-354

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Published: 2011-06-18   Modified: 2016-04-21  

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