2009 Fiscal Year Final Research Report
The ^<17>O MRS/MRI for the tumor oxygen consumption rate in mice
| Project/Area Number |
20790893
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
NARAZAKI Michiko Kyoto University, 大学院・情報学研究科, 特定研究員(科学技術振興) (10467459)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 核磁気共鳴画像(MRI) / 多核種 / 酸素代謝 |
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| Research Abstract |
The tumor oxygen consumption rate in tumor-bearing mice using ^<17>O MRS/MRI was investigated based on the metabolically generated ^<17>O-water from ^<17>O2 gas. ^<17>O images were acquired before and after the inhalation of ^<17>O enriched oxygen gas. The increment in the ^<17>O image intensity due to the metabolically generated H2^<17>O from ^<17>O2 was converted to the quantity of produced H2^<17>O, which was in good agreement with physiological data in literature. We confirmed this method promising as a tool for monitoring the oxygen consumption rate in tumor.
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