2010 Fiscal Year Final Research Report
PD-ECGF-targeted tumor imaging with new radiolabeled uracil derivatives
| Project/Area Number |
20790906
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
NISHIJIMA Ken-ichi Hokkaido University, 大学院・医学研究科, 特任講師 (60364254)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 放射性医薬品 / 血管新生 |
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| Research Abstract |
The angiogenic factor PD-ECGF/TP is expressed at high levels in a variety of solid tumors compared with normal tissue. In this study, we aimed at the development of radiopharmaceuticals for imaging of angiogenesis. To develop a radioprobe for angiogenesis imaging, a radiolabeled uracil-based PD-ECGF/TP inhibitor, BOMU and IIMU were designed and radiosynthesized. These radiolabeled uracil derivatives showed high and specific accumulation of in PD-ECGF/TP-expressing tumors. These finding indicate that radiolabeled uracil deserves further evaluation as a novel single photon emission computed tomography (SPECT) probe for imaging of tumor angiogenesis.
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