2009 Fiscal Year Final Research Report
Combination of hyperthermia and hyperbaric oxygen treatment to improve the antitumor efficacy of chemotherapy or radiotherapy
| Project/Area Number |
20790915
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
OHGURI Takayuki University of Occupational and Environmental Health, Japan, 医学部, 助教 (80469395)
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| Research Collaborator |
MOON Seung dae 産業医科大学, 医学部, 大学院生
YAHARA Katsuya 産業医科大学, 医学部, 助教 (80441830)
KUNUGITA Naoki 国立保健医療科学院, 生活環境部, 部長 (90178020)
NORIMURA Toshiyuki 産業医科大学, 医学部, 教授 (20039530)
KOROGI Yukunori 産業医科大学, 医学部, 教授 (60195691)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 温熱療法 / 高気圧酸素 / 化学療法 / カルボプラチン / 低酸素細胞 |
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| Research Abstract |
The rationale for the use of hyperthermia (HT) or hyperbaric oxygen treatment (HBO) as a chemosensitizer has been reported. However, no experimental study has ever been reported on the combination of HBO and HT to improve the antitumor efficacy of chemotherapy. We confirmed that the combination of HT and HBO can be used to enhance the efficacy of a chemotherapeutic agent of carboplatin in experimental tumor models.
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