2009 Fiscal Year Final Research Report
Development of probes and methods for noninvasive and quantitative assessment of efflux systems in the brain
| Project/Area Number |
20790920
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
OKAMURA Toshimitsu National Institute of Radiological Sciences, 分子イメージング研究センター, 研究員 (80443068)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 放射性医薬品 / PET薬剤 |
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| Research Abstract |
The aim of this study is to develop radioactive probes for noninvasive and quantitative measurement of brain efflux systems. The novel probe readily enters the brain and is converted to its glutathione conjugate, which is specifically transported by an efflux transporter MRP1. The probe can measure brain efflux systems noninvasively and quantitatively.
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