2009 Fiscal Year Final Research Report
Development and evaluation of a novel PET probe for EGFR
| Project/Area Number |
20790921
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | National Institute of Radiological Sciences |
|---|
Principal Investigator |
齋藤 有里子 National Institute of Radiological Sciences, 分子イメージング研究センター, 准技術員 (20446537)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 画像診断 / 放射性医薬品 / 分子イメージング / 腫瘍イメージング |
|---|
| Research Abstract |
It is of key importance to create novel diagnostic and treatment products for tailor-made medicine. In this study, we developed novel molecular probes targeting activated-EGFR which is known to be involved in carcinogenesis and tumor malignancy. Probe retention in cells was correlated with EGFR activation, and the uptake pattern into tissues was dependent on EGFR amount/activation. In addition, tumor growth was dramatically suppressed with consecutive probe injection. This study could help the development of cancer diagnosis and cancer therapy.
|
