2009 Fiscal Year Final Research Report
Development of a radioprobe for quantifying the activity of multidrug resistance protein
| Project/Area Number |
20790924
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
KIKUCHI Tatsuya National Institute of Radiological Sciences, 分子イメージング研究センター, 研究員 (90392224)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 多剤耐性タンパク質 / 放射性プローブ / PET / 脳 |
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| Research Abstract |
The aim of this study is to develop a radioprobe for quantifying the activity of multidrug resistance protein. The in vivo measurement of P-glycoprotein activity would be useful for development of drugs and optimizing the dose, whereas the method has not been established. In this study, we evaluated the compound, which was considered to be a substrate for P-glycoprotein, to achieve the aim. However, the extraction of the compounds from the brain was considered to be mediated by the other unknown transporters.
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