2010 Fiscal Year Final Research Report
PET Imaging for Assessment of Efficacy of EGFR Kinase Inhibitors
| Project/Area Number |
20790926
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Research Institute, Shiga Medical Center |
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Principal Investigator |
KAGAWA Shinya Research Institute, Shiga Medical Center, 主任研究員 (10393191)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 上皮成長因子 / PET / 画像診断 / 癌 / 分子標的 |
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| Research Abstract |
The purpose of this study is to assess the efficacy of I-mIPQA PET imaging for prediction of responsiveness to therapy with EGFR kinase inhibitor gefitinib with orthotopic non-small cell lung carcinoma xenograft in mice. Human lung carcinoma cells PC14GL, H441GL, H3255GL, and H1975GL, expressing different EGFR mutants and various levels of TGFα. In vitro uptake study of I-mIPQA with these lung cancer cell lines, biodistribution study of I-mIPQA in tumor bearing mice with or without inhibitor were performed. I-mIPQA PET imaging: 3 and 24 hours imaging post intravenous injection of radiotracer using microPET were also conducted followed by auroradiograpfy (ARG) study of I-mIPQA after PET imaging with or without treatment with Gefitinib (Iressa), for three days after PET imaging. PET with I-mIPQA would be a promising molecular imaging of different EGFR kinase mutant NSCL carcinomas for prediction of responsiveness to EGFR Kinase inhibitors in patients.
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Research Products
(17 results)
