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2009 Fiscal Year Final Research Report

Enhancing effect in the expression of tumor antigens and T-cell sensitivity against tumor cells after treatment with epigenetic drugs.

Research Project

  • PDF
Project/Area Number 20790930
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionShimane University

Principal Investigator

HARASHIMA Nanae  Shimane University, 医学部, 助教 (60345311)

Project Period (FY) 2008 – 2009
Keywords腫瘍 / 免疫 / エピジェネティクス / 薬剤反応性
Research Abstract

Histone deacetylase inhibitor (HDACi) strikingly induced cell death and decreasing cell viability of the human renal cell carcinoma and prostate cancer cells in dose- and time-dependent manner, although the effect of a DNA methyltransferase inhibitor was not recognized. Moreover, tumor-specific antigens were maintained their gene expression as a target of T-cells which enough recognizes the cancer cells after HDACi treatment.

  • Research Products

    (14 results)

All 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (10 results)

  • [Journal Article] Immunogenic chemotherapy with cyclophosphamide and doxorubicin against established murine carcinoma.2009

    • Author(s)
      Tongu M, Harashima N, Yamada T, Harada T, Harada M
    • Journal Title

      Cancer Immunol Immunother. 59(5)

      Pages: 767-777

    • Peer Reviewed
  • [Journal Article] Roles of proinflammatory cytokines and the Fas/Fas ligand interaction in the pathogenesis of inflammatory myopathies.2009

    • Author(s)
      Kondo M, Murakawa Y, Harashima N, Kobayashi S, Yamaguchi S, Harada M
    • Journal Title

      Immunology 128

      Pages: e589-599

    • Peer Reviewed
  • [Journal Article] Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages.2009

    • Author(s)
      Shimizu Y, Takamori A, Utsunomiya A, Kurimura M, Yamano Y, Hishizawa M, Hasegawa A, Kondo F, Kurihara K, Harashima N, Watanabe T, Okamura J, Masuda T, Kannagi M
    • Journal Title

      Cancer Sci. 100

      Pages: 481-489

    • Peer Reviewed
  • [Journal Article] ( *These authors contributed equally to this work. ) Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells.2008

    • Author(s)
      Takahashi Y*, Harashima N*, Kajigaya S, Yokoyama H, Cherkasova E, McCoy JP, Hanada K, Mena O, Kurlander R, Tawab A, Srinivasan R, Lundqvist A, Malinzak E, Geller N, Lerman MI, Childs RW
    • Journal Title

      J Clin Invest. 118

      Pages: 1099-1109

    • Peer Reviewed
  • [Presentation] TLR3リガンドによる前立腺癌細胞のアポトーシス2009

    • Author(s)
      原田守
    • Organizer
      第39回日本免疫学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
  • [Presentation] TLR3リガンド刺激により誘導されるtype-I IFNを介する前立腺癌細胞の細胞死2009

    • Author(s)
      原嶋奈々江
    • Organizer
      第68回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
  • [Presentation] Immunogenic chemotherapy with cyclophosphamide and adriamycin against established murine colon carcinoma.2009

    • Author(s)
      原田守
    • Organizer
      第13回日本がん免疫学会
    • Place of Presentation
      北九州
    • Year and Date
      2009-06-25
  • [Presentation] 炎症性筋疾患の病態における炎症性サイトカインとFasの役割2008

    • Author(s)
      近藤正宏
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
  • [Presentation] 成人T細胞白血病の免疫学的リスクファクター2008

    • Author(s)
      清水由紀子
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
  • [Presentation] Cyclophosphamideとadriamycinによる抗がん免疫応答の誘導2008

    • Author(s)
      頓宮美樹
    • Organizer
      第67回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
  • [Presentation] 同種造血幹細胞移植後の腎細胞癌患者由来T細胞が認識するHERV-E由来新規腫瘍抗原CT-RCCの同定とその発現解析2008

    • Author(s)
      高橋義行
    • Organizer
      第67回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
  • [Presentation] 一部のHTLV-Iキャリアとくすぶり型ATLはTax特異的T細胞応答の減弱と高プロウイルス量を示す2008

    • Author(s)
      清水由紀子
    • Organizer
      第67回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
  • [Presentation] ATLおよびその前段階におけるTax特異的T細胞の低応答性:免疫学的ATL危険因子とその回避2008

    • Author(s)
      神奈木真理
    • Organizer
      第1回HTLV-1研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-08-24
  • [Presentation] 同種造血幹細胞移植後の腎細胞癌患者由来T細胞が認識する新規腫瘍抗原の同定とその発現解析2008

    • Author(s)
      原嶋奈々江
    • Organizer
      第12回基盤的癌免疫研究会
    • Place of Presentation
      埼玉
    • Year and Date
      2008-07-02

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Published: 2011-06-18   Modified: 2016-04-21  

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