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2009 Fiscal Year Final Research Report

Development of new cellular and gene therapy for liver cirrhosis

Research Project

  • PDF
Project/Area Number 20790936
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionWakayama Medical University

Principal Investigator

UENO Masaki  Wakayama Medical University, 医学部, 助教 (90405465)

Project Period (FY) 2008 – 2009
Keywords再生医学 / 肝硬変 / 遺伝子治療 / 細胞治療 / Hepatocyte growth factor
Research Abstract

In a cirrhotic liver, the hepatic functional reserve are impaired, therefore administration of hepatectomy are limited. Moreover, in order to elongate the survival outcome, therapeutic strategy against cirrhosis is needed. In this study, we demonstrated the administration of the hepatocyte growth factor (HGF) which were recognized as a promoter of cellular proliferation and as an anti-apoptotic or anti-fibrotic factor for injured tissue to drug inducing cirrhosis model and hepatectomy model and revealed improvement of fibrotic status and survival outcome after hepatectomy.

  • Research Products

    (5 results)

All 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] A new prediction model of postoperative complications after major hepatectomy for hepatocellular carcinoma.2009

    • Author(s)
      Ueno M, Uchiyama K, Ozawa S, Hayami S, Kiriyama S, Yamaue H.
    • Journal Title

      Dig Surg. 26

      Pages: 329-9

    • Peer Reviewed
  • [Journal Article] Prognostic impact of treatment modalities on patients with single nodular recurrence of hepatocellular carcinoma.2009

    • Author(s)
      Ueno M, Uchiyama K, Ozawa S, Nakase T, Togo N, Hayami S, Yamue H.
    • Journal Title

      Surg Today 39

      Pages: 675-81

    • Peer Reviewed
  • [Journal Article] Assessment of liver function for successful hepatectomy in patients with hepatocellular carcinoma with impaired hepatic function.2008

    • Author(s)
      Uchiyama K, Mori K, Tabuse K, Ueno M, Ozawa S, Nakase T, Kawai M, Tani M, Tanimura H, Yamaue H.
    • Journal Title

      J Hepatobiliary Pacreat Surg. 15

      Pages: 596-602

    • Peer Reviewed
  • [Presentation] 当科における腹腔鏡補助下肝切除の工夫2010

    • Author(s)
      上野昌樹
    • Organizer
      日本外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-09
  • [Presentation] 肝細胞癌(HCC)に対するHr2以上の肝切除における新たな術後合併症予測式の確立2009

    • Author(s)
      上野昌樹
    • Organizer
      日本外科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-04-03

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

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