2009 Fiscal Year Final Research Report
Development of new cellular and gene therapy for liver cirrhosis
| Project/Area Number |
20790936
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
UENO Masaki Wakayama Medical University, 医学部, 助教 (90405465)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 再生医学 / 肝硬変 / 遺伝子治療 / 細胞治療 / Hepatocyte growth factor |
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| Research Abstract |
In a cirrhotic liver, the hepatic functional reserve are impaired, therefore administration of hepatectomy are limited. Moreover, in order to elongate the survival outcome, therapeutic strategy against cirrhosis is needed. In this study, we demonstrated the administration of the hepatocyte growth factor (HGF) which were recognized as a promoter of cellular proliferation and as an anti-apoptotic or anti-fibrotic factor for injured tissue to drug inducing cirrhosis model and hepatectomy model and revealed improvement of fibrotic status and survival outcome after hepatectomy.
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