2009 Fiscal Year Final Research Report
Induction of transplant tolerance by regulatory T cell in rat liver transplantation
| Project/Area Number |
20790945
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
TAKAYASHIKI Tsukasa Chiba University, 医学部・附属病院, 助教 (30456024)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 肝臓外科学 |
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| Research Abstract |
In present study, we established transplant tolerance in orthotropic rat liver transplantation and transplant tolerance was transferred adoptively by peripheral lymphocyte, within regulatory T cells. CD4 (+) T cells or CD8 (+) T cells from peripheral lymphocyte of long term survivor were adoptive transferred to naive rat after cell sorting and we revealed that both groups were able to induce transplant tolerance in rat liver transplantation. These results suggested that regulatory T cells were existed not only in population of CD4 (+) CD25 (+) T cells but in CD8 (+) T cells.
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Research Products
(4 results)
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[Journal Article] Significance of repeated resection for recurrent intrahepatic cholangiocarcinoma.2009
Author(s)
Ohtsuka M, Kimura F, Shimizu H, Yoshidome H, Kato A, Yoshitomi H, Frukawa K, Mitsuhashi N, Takeuchi D, Takayashiki T, Suda K, Miyazaki M.
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Journal Title
Hepatgastroenterology. 56
Pages: 1-5
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[Journal Article] Usefulness of intraoperative fluorescence imaging to evaluate local anatomy in Hepatobiliary surgery.2008
Author(s)
Mitsuhashi N, Kimura F, Shimizu H, Yoshidome H, Ohtsuka M, Kato A, Yoshitomi H, Nozawa S, Frukawa K, Takeuchi D, Takayashiki T, Suda K, Igarashi T, Miyazaki M.
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Journal Title
J Hepatobiliary Pancreat Surg. 15
Pages: 508-514
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