Analysis of immune-responses as antigen spreading in patients treated with cancer immunotherapy

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790950
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: KITANO Shigehisa Mie University, 大学院・医学系研究科, 助教 (60402682)
• Project Period (FY): 2008 – 2009
• Keywords: 腫瘍免疫学 / 臨床腫瘍学

Research Abstract

A phase I clinical trial of CHP-HER2 complex vaccine with GM-CSF was carried out. In some patients not only HER2 specific T cell immune responses but also MAGE-A4 specific T cell responses was detected, suggesting antigen spreading triggered by the vaccination with CHP-HER2. Though these data are based on a small phase I study and should be cautiously interpreted, patients induced immune responses had shown no disease progression for longer periods (range, 9-40 month) compared to no responders (range, 2-10 month).

Research Products

• [Journal Article] Antibody responses against NY-ESO-1 and HER2 antigens inpatients vaccinated with combinations of cholesteryl pullulan (CHP)-NY-ESO-1 and CHP-HER2 with OK-432. (2009)
  • Author(s): Aoki M., Ueda S., Hirayama M., Nishikawa H., Kitano S., Ikeda H., Toyoda H., Tanaka K., Kanai K., Takabayashi A., Imai H., Shiraishi T., Sato E., Wada H., Nakayama E., Takei Y., Katayama N., Shiku H., Kageyama S.
  • Journal Title: Vaccine (in press, peer reviewed)
• [Journal Article] Rapid αβTCR-mediated responses in gamma delta T cells transduced with cancer-specific TCR genes. (2009)
  • Author(s): Hiasa A., Nishikawa H., Hirayama M., Kitano S., Okamoto S., Chono H., Yu S.S., Mineno J., Tanaka Y., Minato N., Kato I. Shiku H.
  • Journal Title: Gene Therapy 16(peer reviewed) Pages: 620-628
• [Journal Article] Deletion of chromosome arm 15q in a case of minimally differentiated hypoplastic AML-M0. (2008)
  • Author(s): Fujieda A., Masuya M., Kitano S., Miyazaki K., Yazaki A., Sugimoto Y., Usui E., Miyata E., Shibasaki T., Yamamura K., Ohishi K., Nishii K, Nakase K., Takeuchi T. Katayama N.
  • Journal Title: Cancer Genetics and Cytogenetics 184(1)(peer reviewed) Pages: 57-61
• [Journal Article] Long-term phenotypic, functional and genetic stability of cancer-specific T-cell receptor (TCR)αβgenes transduced to CD8+ T cells. (2008)
  • Author(s): Hiasa A., Hirayama M., Nishikawa H., Kitano S., Nukaya I., Yu SS., Mineno J., Kato I., Shiku H.
  • Journal Title: Gene Therapy 15(peer reviewed) Pages: 695-699
• [Journal Article] Humoral immune responses in patients vaccinated with 1-146 HER2 protein complexed with cholesteryl pullulan nanogel. (2008)
  • Author(s): Kageyama S., Kitano S., Hirayama M., Nagata Y., Imai H., Shiraishi T., Akiyoshi K., Scott AM., Murphy R., Hoffman EW., Old LJ., Katayama N., Shiku H.
  • Journal Title: Cancer Sci. 99(3)(peer reviewed) Pages: 601-607
• [Presentation] Skeletal metastases in gastric cancer:analysis of skeletal-related events and plasma endothelin-1. (2009)
  • Author(s): Mizuno T., Nomura H., Saito K., Yamashita Y., Kitano S., Miyata E., Tamaru S., Hiasa A., Kageyama S., Katayama N.
  • Organizer: ESMO annual meeting.
  • Place of Presentation: Berlin, Germany.
  • Year and Date: 20090920-20090924
• [Presentation] 教育講演(パネリスト) (2009)
  • Author(s): 北野滋久
  • Organizer: 第6回日本乳癌学会中部地方会
  • Place of Presentation: 浜松
  • Year and Date: 20090912-20090913
• [Presentation] Combination cancer vaccine of CHP-NY-ESO-1 and CHP-HER2 with immuno-adjuvant, OK-432, for chemorefractory metastatic or recurrent esophageal cancer patients. (2008)
  • Author(s): Ueda S., Aoki M., Nishikawa H., Hirayama M., Kitano S., Hayashi E., Kanai M., Takabayashi A., Shiku H., Kageyama S.
  • Organizer: 99th AACR Annual Meeting.
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 20080412-20080416
• [Presentation] Rapid αβTCR-mediated responses inγδT cells transduced with cancer-specific TCR. (2008)
  • Author(s): Hiasa A., Nishikawa H., Hirayama M., Kitano S., Nakayama E., Okamoto S., Chono H., Yu S.S., Mineno, J., Tanaka Y., Minato N., Kato I., Shiku H.
  • Organizer: 99th AACR Annual Meeting.
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 20080412-20080416
• [Presentation] Functional analyses of T cells transduced with MAGE-A4-specificαβtype TCR genes. (2008)
  • Author(s): Hirayama M., Hiasa A., Nishikawa H., Shirakura Y., Ikeda H., Kitano S., Tajima K., Nukaya I., Yu S.S., Mineno J., Ito M., Kato I., Shiku H.
  • Organizer: 99th AACR Annual Meeting.
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 20080412-20080416
• [Presentation] 原発不明癌に対するドセタキセル/カルボプラチン併用療法の検討. (2008)
  • Author(s): 北野滋久、水野聡朗、斉藤佳菜子、野村英樹、宮田恵理、田丸智巳、日浅厚則、中瀬一則、影山慎一、片山直之
  • Organizer: 第6回日本臨床腫瘍学会
  • Place of Presentation: 福岡
  • Year and Date: 20080320-20080321