Research on improving safety of living donor liver transplantation using small-for-size graft

2010 Fiscal Year Final Research Report

• Project/Area Number: 20790957
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Kobe University
• Principal Investigator: OGATA Satoshi Kobe University, 医学研究科, 医学研究員 (40444583)
• Project Period (FY): 2008 – 2010
• Keywords: 生体肝移植 / 過小グラフト / 肝静脈再建 / 術後合併症 / 術後肝機能

Research Abstract

The purpose of the present study is to evaluate new criteria for donor selection in living donor liver transplantation(LDLT)of the small-for-size liver graft.
We have tried to grasp the post operational changes of hepatic veins in a three dimensional asepect,and designed a new procedure for hepatic vein reconstruction so as to accommodate the changes.
This not only gives patients who had been formerly considered to be outside the liver transplantation criteria because of the absent of donor with enough graft volume a chance to safely undergo transplantations, but has also implies the possibility of improving the safety of donor, which is the primary importance in LDLT.
Our study has obtained a result of high significance.

Research Products

• [Journal Article] 生体ドナーの安全とレシピエントの予後向上をめざして (2010)
  • Author(s): 尾形哲、幕内雅敏
  • Journal Title: 肝胆膵画像 12 Pages: 11-16
• [Journal Article] 生体肝移植後の胆管合併症の診断と治療 (2010)
  • Author(s): 辻野武、尾形哲、幕内雅敏
  • Journal Title: 肝胆膵画像 12 Pages: 79-88
• [Journal Article] Recovery of Liver Function After the Cessation of Preoperative Chemotherapy for Colorectal Liver Metastasis (2010)
  • Author(s): Takamoto T, Hashimoto T, Sano K, Maruyama Y, Inoue K, Ogata S, Takemura T, Kokudo N, Makuuchi M.
  • Journal Title: Ann Surg Oncol
• [Journal Article] 手術症例報告経皮的肝灌流化学療法にてCRとなった肝移植後両葉多発肝細胞癌の1例 (2009)
  • Author(s): 木下秘我、尾形哲、具英成
  • Journal Title: 手術 63(4) Pages: 531-534
• [Presentation] 日本外科学会移植 (2010)
  • Author(s): 幕内雅敏, 尾形哲
  • Organizer: 特別ビデオセッション 生体肝移植の技術革新
  • Year and Date: 20100000
• [Presentation] 国際肝癌シンポジウム神戸 (2009)
  • Author(s): Satoshi Ogata, Keiji Sano, Yoshikazu Maruyama, Kazuto Inoue, Takuya Hashimoto, Takeshi Takamato, Yujiro Nishioka, Masatoshi Makuuchi.
  • Organizer: Pretransplant Splenectomy Initiates Early Antiviral Therapy for Recurrent Hepatitis C after Living Donor Liver Transplantation for Hepatocellular Carcinoma
  • Year and Date: 20090000
• [Presentation] 消化器外科学会シンポジウム (2008)
  • Author(s): 尾形哲, 福本巧、高橋応典、冨永正寛、岩崎武、楠信也、木戸正浩、具英成
  • Organizer: 生体肝移植における脈管再建部の合併症成人生体部分肝移植における移植後のグラフト回転を考慮した新しい肝静脈再建法
  • Year and Date: 20080000
• [Presentation] 日本肝移植研究会要望演題 (2008)
  • Author(s): 尾形哲, 福本巧、高橋応典、冨永正寛、岩崎武、楠信也、木戸正浩、具英成
  • Organizer: 分枝を含めた肝静脈再建の適応と工夫成人生体肝移植後のグラフト回転を考慮した新しい肝静脈再建法
  • Year and Date: 20080000
• [Presentation] 日本移植学会 (2008)
  • Author(s): 尾形哲, 福本巧、高橋応典、冨永正寛、岩崎 武、楠信也、木戸正浩、具英成
  • Organizer: 生体肝移植前に免疫抑制剤の投与を必要とした急性赤芽球癆合併原発性硬化性胆管炎の1例
  • Year and Date: 20080000
• [Presentation] 国際肝移植学会 (2008)
  • Author(s): Satoshi Ogata, Takumi Fukumoto, Masahiro Tominaga, Takeshi Iwasaki, Nobuya Kusunoki, Masahiro Kido, Yonson Ku.
  • Organizer: Should we return to the left in adult to adult living donor liver transplantation?
  • Year and Date: 20080000
• [Presentation] 日韓肝移植フォーラム (2008)
  • Author(s): Satoshi Ogata, Takumi Fukumoto, Masahiro Tominaga, Takeshi Iwasaki, Nobuya Kusunoki, Masahiro Kido, Yonson Ku.
  • Organizer: Should we return to the left in adult to adult living donor liver transplantation?
  • Year and Date: 20080000
• [Presentation] 肝癌治療シミュレーション研究会 (2008)
  • Author(s): 尾形哲, 福本巧、高橋応典、冨永正寛、岩崎武、楠信也、木戸正浩、具英成
  • Organizer: 右葉成人生体肝移植後のグラフト回転による肝静脈の3次元的変化
  • Year and Date: 20080000
• [Presentation] 近畿肝移植検討会 (2008)
  • Author(s): 尾形哲, 福本巧、高橋応典、冨永正寛、岩崎武、楠信也、木戸正浩、具英成
  • Organizer: 右3区域切除・肝灌流後に循環障害を来たし、肝移植に至った1例
  • Year and Date: 20080000