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2009 Fiscal Year Final Research Report

Prevention of bacterial translocation in small bowel transplantation and study for immune syetem of small intestine.

Research Project

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Project/Area Number 20790959
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionThe University of Tokushima

Principal Investigator

HIGASHIJIMA Jun  The University of Tokushima, 医学部・歯学部附属病院, 医員 (30467815)

Co-Investigator(Renkei-kenkyūsha) SHIMADA Mitsuo  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (10216070)
Project Period (FY) 2008 – 2009
Keywords腸虚血再灌流傷害 / バクテリアルトランスロケーション小腸粘膜損傷 / 炎症性サイトカイン / egr-1
Research Abstract

[Background] The purpose of this study was to clarify the effect of GGA to prevent the ischemia-reperfusion injury in the small intestine. [Methods] 1, Male Wistar rats were divided into two groups. Control group(n=4), was administered a vehicle 4 hour before ischemic condition. GGA group(n=4) was administered GGA (100mg/kg) 4 hour before ischemic condition. Ischemia- reperfusion injury in the small intestine was induced by 40 minute clamping of the root of superior mesenteric artery. After 60 minute reperfusion, cytokines in the blood were measured by RT-PCR. And the extent of damage of the mucosa was evaluated by immunohistochemical stain of HSP70.
[Results] IL-1 was significantly lower in GGA group than control group (GGA vs cont : 1.78±0.90 vs 0.92±0.21, p<0.05).IL-6 was significantly lower in GGA group than control group (GGA vs cont : 78.5±40.0 vs 8.6±5.1, p<0.05). INF-_Y, Caspase 3 and TNT-α showed no significant changes. Egr- 1 was significantly lower in GGA group than control group(GGA vs cont 2.02±1.20 vs 0.44±0.28, p<0.05). HSP70 was overexpressed in the GGA group. [ Conclusion] HSP induced by GGA suppressed expressions of Egr-1 and inflammatory cytokines,produced by ischemia-reperfusion injury of small intestine.

  • Research Products

    (9 results)

All 2009 2008

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (2 results)

  • [Journal Article] Sonic hedgehog relates to colorectal carcinogenesis.2009

    • Author(s)
      Yoshikawa K, Shimada M, Miyamoto H, Higashijima J, Miyatani T, Nishioka M, Kurita N, Iwata T, Uehara H.
    • Journal Title

      J Gastroenterol 44(11)

      Pages: 1113-7

    • Peer Reviewed
  • [Journal Article] Effect of splenectomy on antitumor immune system in mice.2009

    • Author(s)
      Higashijima J, Shimada M, Chikakiyo M, Miyatani T, Yoshikawa K, Nishioka M, Iwata T, Kurita N.
    • Journal Title

      Anticanceer Res 29(1)

      Pages: 385-93

    • Peer Reviewed
  • [Journal Article] Increased risk of lymph node metastasis in mucosal gastric cancer' with extra indication for endoscopic mucosal resection.2009

    • Author(s)
      Yoshikawa K, Hiki N, FukunagaT, Tokunaga M, YamamotoY, MikiA, Ogawa K, Higashijima J, Ohyama S, SetoY, Shimada M, Yamaguchi T.
    • Journal Title

      J Am Coll Surg 208(6)

      Pages: 1046-50

    • Peer Reviewed
  • [Journal Article] Kampo medicine "Dai-kenchu-to" prevents bacterial translocation in rats.2008

    • Author(s)
      Yoshikawa K, Kurita N, Higashijima J, Miyatani T, Miyamoto H, Nishioka M, Shimada M
    • Journal Title

      Dig Dis Sci. 53(7)

      Pages: 1824-31

    • Peer Reviewed
  • [Journal Article] Beneficial effects of Kampo medicine Inchin-ko-to on liver function and regeneration after hepatectomy in rats.2008

    • Author(s)
      Ogasawara T, Y, Ikemoto T, Imura S, Shimada M
    • Journal Title

      Hepatol Res. 38(8)

      Pages: 818-24

    • Peer Reviewed
  • [Journal Article] Influence of Dai-kenchu-to (DKT) on human portal blood flow.2008

    • Author(s)
      Ogasawara T, Morine Y, Ikemoto T, Imura S, Fujii M, Soejima Y, Shimada M
    • Journal Title

      Hepatogastroenterology 55(82-83)

      Pages: 574-7

  • [Journal Article] Does Roux-en Y reconstruction with jejunal pouch after total gastrectomy prevent complications of postgastrectomy?2008

    • Author(s)
      Kurita N, Shimada M, Chikakiyo M, Higashijima J, Yoshikawa K, Miyamoto H, Nishioka M Iwata T.
    • Journal Title

      Hepatogastroenterology 55

      Pages: 1851-4

    • Peer Reviewed
  • [Presentation] CPT-11による腸管粘膜障害と大建中湯の予防効果2008

    • Author(s)
      近清素也、島田光生、小松正人、中尾寿宏、宮谷知彦、東島潤、吉川幸造、西岡将規、岩田貴、栗田信浩
    • Organizer
      第46回日本癌治療学会総会
    • Place of Presentation
      ワークショップ
    • Year and Date
      20081031-20081101
  • [Presentation] ラット小腸虚血再灌流傷害に対するGeranylgeranylacetone(GCA)誘導heat shock protein(HSP)の軽減効果の検討2008

    • Author(s)
      小松正入、岩田貴、近清素也、吉川幸造、東島潤、西岡将規、栗田信浩、島田光生
    • Organizer
      第108回日本外科学会定期学術集会
    • Year and Date
      2008-05-15

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Published: 2011-06-18   Modified: 2016-04-21  

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