2009 Fiscal Year Final Research Report
Elucidation of significance of lymphangiogenesis and lymph node micrometastasis in lymphatic metastasis
| Project/Area Number |
20790963
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
KURAHARA Hiroshi Kagoshima University, 医学部・歯学部附属病院, 医員 (70464469)
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| Project Period (FY) |
2008 – 2009
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| Keywords | リンパ節転移 / 微小転移 / リンパ管新生 / 微小環境 / 腫瘍関連マクロファージ |
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| Research Abstract |
Pancreatic cancer induces lymphangiogenesis in the primary tumor and the regional lymph nodes by producing VEGF-C. Dissemination of cancer cells to other organs was promoted through the increased lymphatic vessels. And pancreatic cancer educates macrophages which were recruited to the tumor to help tumor progression. The educated macrophages increase lymphatic vessels in cooperation with the cancer cells, and further facilitate metastasis of cancer cells.
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