2009 Fiscal Year Final Research Report
Gene expression analyses for predicting lymph node metastasis of T1 colorectal cancer.
| Project/Area Number |
20790965
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
OKU Yoshimasa Wakayama Medical University, 医学部, 学内助教 (10453185)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 早期大腸癌 / 遺伝子診断 / バイオマーカー |
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| Research Abstract |
Prediction of lymph node metastasis before treatment enables individualized treatment of colorectal cancer (CRC), especially in T1 CRC. We have reported that 10 genes were found to correlate with dedifferentiation at the invasion front of colorectal cancer by cDNA microarray analysis (Clin Cancer Res 2008 ; 14 : 7215-7222). These 10 genes might be clinical markers to predict the lymph node metastasis in CRC. Real-time RT-PCR and immunohistochemical studies showed expression levels of CITED1 were statistically related with lymph node metastasis in T1 CRC. CITED1 expression level may predict lymph node metastasis in T1 CRC.
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Research Products
(9 results)
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[Journal Article] Identification of the molecular mechanisms for dedifferentiation at the invasion front of colorectal cancer by a gene expression analysis.2008
Author(s)
Oku Y, Shimoji T, Takifuji K, Hotta T, Yokoyama S, Matsuda K, Higashiguchi T, Tominaga T, Nasu T, Tamura K, Matsuura M, Miyata S, Kato Y, Yamaue H, Miki Y
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Journal Title
Clin Cancer Res. 14(22)
Pages: 7215-22
Peer Reviewed
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[Presentation] StageII大腸癌の再発形式の検討2009
Author(s)
奥喜全, 瀧藤克也, 堀田司, 横山省三, 松田健司, 渡辺高士, 橋本忠通, 田村耕一, 家田淳司, 山本直之, 山上裕機
Organizer
第71回日本臨床外科学会
Place of Presentation
京都
Year and Date
2009-11-02
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[Presentation] 腹腔鏡補助下低位前方切除術の有用性2009
Author(s)
奥喜全, 瀧藤克也, 堀田司, 横山省三, 松田健司, 渡辺高士, 那須亨, 田村耕一, 家田淳司, 山本直之, 山上裕機
Organizer
第64回日本消化器外科学会
Place of Presentation
大阪
Year and Date
2009-07-17
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[Presentation] StageII大腸癌の治療戦略2009
Author(s)
奥喜全, 瀧藤克也, 堀田司, 横山省三, 松田健司, 渡辺高士, 那須亨, 田村耕一, 家田淳司, 山本直之, 山上裕機
Organizer
第71回大腸癌研究会
Place of Presentation
大宮
Year and Date
2009-07-03
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[Presentation] 大腸癌先進部脱分化に関与する機能ネットワークの構築2008
Author(s)
奥喜全, 下地尚, 瀧藤克也, 堀田司, 横山省三, 松田健司, 東口崇, 富永敏治松浦正明, 宮田敏, 加藤洋, 野田哲生, 三木義男, 山上裕機
Organizer
第63回日本大腸肛門病学会
Place of Presentation
東京
Year and Date
2008-10-17
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[Presentation] 網羅的遺伝子発現解析による大腸癌先進部脱分化規定因子の同定2008
Author(s)
奥喜全, 下地尚, 瀧藤克也, 堀田司, 横山省三, 松田健司, 東口崇, 富永敏治松浦正明, 宮田敏, 加藤洋, 野田哲生, 三木義男, 山上裕機
Organizer
第17回日本癌転移学会
Place of Presentation
鹿児島
Year and Date
2008-07-25
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[Presentation] リンパ節転移のないMP癌(T2-Stage1)大腸癌の再発危険因子の検討2008
Author(s)
奥喜全, 瀧藤克也, 堀田司, 横山省三, 松田健司, 冨永敏治, 渡辺高士, 那須亨, 田村耕一, 家田淳司, 山上裕機
Organizer
第69回大腸癌研究会
Place of Presentation
横浜
Year and Date
2008-07-04
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