2009 Fiscal Year Final Research Report
Promoter hypermethylation of resected regional lymph nodes of esophageal squamous cell carcinoma.
| Project/Area Number |
20790971
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
NASU Motomi Juntendo University, 医学部, 助教 (90384114)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 食道癌 / メチル化 / リンパ節転移 |
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| Research Abstract |
To detect DNA promoter methylation, we introduce two new techniques as ; entire process performed in a single tube via the use of silica superparamagnetic beads, and real-time quantitative fluorescence resonance energy transfer sensing with quantum dots. These technique successfully increased detection throughput. However, there are no statistically significant correlation between molecular properties of tumors, normal control tissue, metastasis on lymph nodes and normal lymph nodes from resented esophageal squamous cell carcinoma.
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