2009 Fiscal Year Final Research Report
Inhibitory effects of an anti-rheumatic agent T-614 on experimental hepatocellular carcinoma models
| Project/Area Number |
20790973
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
SAKAMOTO Taro Jikei University School of Medicine, 医学部, 助教 (60366234)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | T-614 / 血管新生 / 肝細胞癌 / 治療 |
|---|
| Research Abstract |
Anti-rheumatic agent T-614 significantly suppressed serum concentration of interleukin-8(IL-8), tumor size, and the number of tumors in the rat hepatocellular carcinoma(HCC) models. In addition, immunohistochemical staining of the rat liver (both normal hepatocytes and HCC cells) using anti-CD31 revealed significant decrease in CD 31 positive cells. Since IL-8 plays an important role in angiogenesis through CD31 molecule, these results suggest that T-614 may contribute as an anti-angiogenic therapy in HCC.
|
