Expression and role of Cytochrome P450 2A6 in colorectal cancer

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790976
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Nippon Medical School
• Principal Investigator: MATSUDA Yoko Nippon Medical School, 医学部, 助教 (20363187)
• Project Period (FY): 2008 – 2009
• Keywords: Cytochrome P450 / 大腸癌 / 線維芽細胞増殖因子受容体

Research Abstract

Cytochrome P450 (CYP) is one of the phase I enzymes and is found abundantly in the body. In colorectal carcinomas (CRC), CYP has important roles in the metabolisms of carcinogens and anti-tumor drugs. It has been reported that the expression and gene polymorphisms of CYP correlate with a risk of CRC. Previously, we have reported the expression of CYP2A6 in colorectal adenocarcinomas and adenomas. In ulcerative colitis, CYP2A6 was expressed in the regenerative mucosa. Furthermore, overexpression of fibroblast growth factor 2IIIc (FGFR2IIIc) was observed in colorectal adenocarcinomas, and FGFR2IIIc has important roles in carcinogenesis and the progression of CRC. There is a possibility that the present study will lead to the development of new therapeutic strategies for CRC.

Research Products

• [Journal Article] Morphological and cytoskeletal changes of pancreatic cancer cells in three-dimensional spheroidal culture.
  • Author(s): Matsuda Y, Ishiwata T, Kawamoto Y, Kawahara K, Peng W, Yamamoto T, Naito Z.
  • Journal Title: Med Mol Morphol (in press)
• [Journal Article] Enhanced expression of lumican inhibited the attachment and growth of human embryonic kidney 293 cells.
  • Author(s): Ishiwata T, Yamamoto T, Kawahara K, Kawamoto Y, Matsuda Y, Ishiwata S, Naito Z.
  • Journal Title: Exp Mol Pathol (in press)
• [Presentation] Expression and role of fibroblast growth factor receptor 2IIIc in colorectal adenocarcinoma. (2009)
  • Author(s): Matsuda Y
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20090900
• [Presentation] 大腸癌における線維芽細胞増殖因子受容体Fibroblast growth factor receptor 2IIIcの発現と役割. (2009)
  • Author(s): 松田陽子
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都
  • Year and Date: 20090500
• [Presentation] Fibroblast growth factor receptor 2 IIIc development of colorectal adenocarcinoma. (2009)
  • Author(s): Matsuda Y
  • Organizer: The 100th Annual Meeting of American Association for Cancer Research
  • Place of Presentation: コロラド州デンバー
  • Year and Date: 20090400