2009 Fiscal Year Final Research Report
Molecular diagnosis and carcinogenetic risk evaluation for lung cancer using methylation-specific DNA microarray
| Project/Area Number |
20790978
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Yamagata University |
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Principal Investigator |
ENDO Makoto Yamagata University, 医学部, 非常勤講師 (90420067)
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| Project Period (FY) |
2008 – 2009
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| Keywords | メチル化 / 肺癌 / メチル化診断チップ |
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| Research Abstract |
We devloped a fiber-type DNA microarray on which methylated sequence probes were mounted, and quantitatively analyzed DNA methylation rates (MRs) of 4 cancer-related genes of CpG island using it. In recurrent group rates of methylated RUNX3 was significantly higher than survivor. Analysis of DNA methylation status using DNA microarray could be a promising method for risk assessment in the recurrence of lung cancer.
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