2009 Fiscal Year Final Research Report
Role of Toll-like receptor 4 in myocardial ischemic-reperfusion injury
| Project/Area Number |
20790987
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Mie University |
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Principal Investigator |
SHIN Shomura Mie University, 医学部・附属病院, 医員 (70452224)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 外科 / 移植・再生医療 / シグナル伝達 / 循環器・高血圧 |
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| Research Abstract |
Ischemic preconditioning is mediated a MyD88-independent pathway, leading to NF-κB activation and protection against myocardial ischemic-reperfusion injury. We conclude that an activation of MyD88 or TRIF, which are associate proteins of Toll-like receptor 4, would regulate a role of NF-κB to injure or protect myocardium.
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