2009 Fiscal Year Final Research Report
Protective Actions of Adiponectin on Cerebral Ischemia-reperfusion Injury.
| Project/Area Number |
20791008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyoto University |
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Principal Investigator |
NISHIMURA Masaki Kyoto University, 医学研究科, 助教 (60452348)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 脳卒中 / 肥満 / 脳血流 / 脳梗塞 / アディポネクチン |
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| Research Abstract |
Adiponectin is a fat-derived plasma protein that has beneficial actions on cardiovascular disorders. Low level of plasma adiponectin is associated with increased mortality following ischemic stroke. However, the causal role of adiponectin in ischemic stroke is unknown. APN-KO mice exhibited enlarged brain infarction and increased neurological deficits following ischemia-reperfusion compared with WT mice. Conversely, adenovirus-mediated supplementation of adiponectin significantly reduced cerebral infarct size in WT and APN-KO mice. APN-KO mice showed decreased cerebral blood flow during ischemia by laser speckle flowmetry methods. These data provide a novel evidence that adiponectin exerts a cerebroprotective action. Adiponectin could represent a molecular target for the prevention of ischemic stroke
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