2010 Fiscal Year Final Research Report

Plaque visualization and hemodynamic analysis with magnetic resonance imaging in swine carotid atherosclerosis model

Research Project

Project/Area Number	20791009
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Cerebral neurosurgery
Research Institution	Kyoto University
Principal Investigator	ISHII Akira Kyoto University, 医学研究科, 助教 (30467469)
Project Period (FY)	2008 – 2010
Keywords	MRI / 不安定プラーク / 頚動脈狭窄症
Research Abstract	The purpose of the present study is to elucidate the role of hemodynamics in atherosclerosis by experimental induction of atherosclerotic plaque in the swine carotid artery. Complex atherosclerotic plaque was successfully induced in the lesion distal to surgical partial ligation. Systolic and diastolic flow velocity were obtained with phase contrast sequence in 3.0 Tesla MRI. Wall shear stress was calculated with the obtained dataset. Shear stress was maintained high in the lesion distal to surgical partial ligation due to unidirectional jet flow. By contrast, in the lesion proximal to ligation, shear stress was found to oscillate during cardiac cycle. Low wall shear stress may contribute to plaque formation in this animal model.